Journal of Zhejiang University SCIENCE B

, Volume 10, Issue 7, pp 493–498 | Cite as

Advances in researches on the immune dysregulation and therapy of severe acute pancreatitis

  • Xi-ping Zhang
  • Han-qing Chen
  • Fang Liu
  • Jie Zhang


During the development and progression of severe acute pancreatitis (SAP), conspicuous immune dysregulation develops, which is mainly manifested as excessive immune response in the early stage and immunosuppression in the late stage. This process involves complex changes in a variety of immune molecules and cells, such as cytokines, complements, lymphocytes, and leukocytes. With the gradual deepening of studies on the development and progression of SAP, the role of immune dysregulation in the pathogenesis of SAP has attracted more and more attention. In this article, we review the advances in research on the immune dysregulation in SAP and the immunotherapy of this disease through exploring the formation of excessive immune response and immune suppression as well as their mutual transformation.

Key words

Severe acute pancreatitis (SAP) Immune Dysregulation Treatment 

CLC number



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Copyright information

© Zhejiang University and Springer-Verlag GmbH 2009

Authors and Affiliations

  • Xi-ping Zhang
    • 1
  • Han-qing Chen
    • 2
  • Fang Liu
    • 3
  • Jie Zhang
    • 2
  1. 1.Department of General SurgeryHangzhou First People’s HospitalHangzhouChina
  2. 2.The First College of Clinical MedicineZhejiang University of Traditional Chinese MedicineHangzhouChina
  3. 3.Department of Acupuncture and MoxibustionHangzhou Hospital of Red Cross SocietyHangzhouChina

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