Journal of Zhejiang University SCIENCE B

, Volume 9, Issue 2, pp 90–92 | Cite as

Mitochondrion and its related disorders: Making a comeback

  • Xian-ning Zhang
  • Ming Qi
Short Review


The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.

Key words

Mitochondria Mitochondrial disorder Mutation 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Zhejiang University-Adinovo Center for Genetic and Genomic MedicineZhejiang UniversityHangzhouChina
  2. 2.James D. Watson Institute of Genome SciencesZhejiang UniversityHangzhouChina
  3. 3.National Education Base for Basic Medical SciencesZhejiang UniversityHangzhouChina

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