Journal of Zhejiang University SCIENCE B

, Volume 7, Issue 12, pp 969–973 | Cite as

Regularities in the E. coli promoters composition in connection with the DNA strands interaction and promoter activity

  • Berezhnoy Andrey Yu 
  • Shckorbatov Yuriy G. 
  • Hisanori Kiryu 


The energy of interaction between DNA strands in promoters is of great functional importance. Visualization of the energy of DNA strands distribution in promoter sequences was achieved. The separation of promoters in groups by their energetic properties enables evaluation of the dependence of promoter strength on the energetic properties. The analysis of groups (clusters) of promoters distributed by the energy of DNA strands interaction in −55, −35, −10 and +6 sequences indicates their connection with the transcriptional activity.

Key words

DNA sequence Promoter strength DNA chains interaction energy DNA sequences classification 

CLC number



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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Berezhnoy Andrey Yu 
    • 1
  • Shckorbatov Yuriy G. 
    • 2
  • Hisanori Kiryu 
    • 3
  1. 1.National Scientific CenterKharkov Physical-Technical InstituteKharkovUkraine
  2. 2.Institute of BiologyKharkov National UniversityKharkovUkraine
  3. 3.Computational Biology Research CenterNational Institute of Advanced Industrial Science and TechnologyTokyoJapan

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