Abstract
Hypertension is one of the most prevalent diseases in the developed and developing countries. Based on the long historical association and the provocative findings of blood pressure effects at low level of lead exposure a study was carried out to determine if an association existed between low blood lead concentration and hypertension. In this study the effects of low-level exposure to lead on blood pressure were examined among 244 adults using atomic absorption spectrometer. For quality assurance purpose certified reference materials i.e., Animal blood A-13, Bovine liver 1577 and cotton cellulose V-9 from IAEA (International Atomic Energy Agency) and NIST (National Institute of Standard Technology) were analyzed under identical experimental conditions. The mean age of hypertensive adults was 52 years (range 43∼66). The mean values of systolic and diastolic blood pressure were (209±11.7) (range 170∼250) and (117±2.9) (range 105}140) mmHg respectively. Blood lead concentration ranged from 78∼201 μg/L with a mean of 139 μg/L and 165∼497 μg/L with a mean of 255 μg/L in normal and hypertensive adults respectively. Increase in systolic blood pressure was significantly predictive with increase in blood lead levels. Body mass index (BMI) and lipid profile including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride correlated with blood pressure.
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References
Bargman, R.F., 1985. Dietary factors in essential hypertension. Prog. Food Nutr. Sci., 9(1–2):109–147.
Batuman, V., Landy, E., Marcsaka, J.K., Wedeen, R., 1983. Contribution of lead to hypertension with renal impairment. N. Engl. J. Med., 309:17–21.
Behne, D., 1981. Sources of error in sampling and sample preparation for trace element analysis in medicine. J. Clin. Chem. Clin. Biochem., 19:115–120.
Bhardwaj, S., Chandra, O., Khan, A.S., 1991. Serum and urinary lead levels in hypertension. Indian J. Pharmac., 23:69–77.
Brainina, K., Schafer, H., Ivanova, A., Khanina, R., 1996. Determination of copper, lead and cadmium in whole blood by stripping voltametry with the use of graphite electrode. Anal. Chim. Acta, 330(2–3):175–181. [doi:10.1016/0003-2670(96)00181-X]
Brockhaus, A., Freier, I., Ewers, U., Jermann, E., Dolgner, R., 1983. Levels of cadmium and lead in blood in relation to smoking, sex, occupation, and other factors in an adult population of FRG. Int. Arch. Occup. Environ. Health, 52(2):167–175. [doi:10.1007/BF00405420]
Cheng, Y., Schwartz, J., Sparrow, D., Aro, A., Weiss, S.T., Hu, H., 2001. Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension the normative aging study. American J. Epidemiol., 153(2):164–171. [doi:10.1093/aje/153.2.164]
Granadillo, V.A., Tahan, J.E., Salgado, O., 1995. The influence of the blood levels of lead, aluminum and vanadium upon the arterial hypertension. Clin. Chim. Acta, 233(1–2):47–59. [doi:10.1016/0009-8981(94)05966-V]
Harlan, W.R., 1998. The relationship of blood lead levels to blood pressure in the US population. Environ. Health Perspect., 78:9–14.
Kurppa, K., Hietanen, E., Klockars, M., Partinen, M., Rantannen, J., Ronnemaa, T., Viikari, J., 1984. Chemical exposures at work and cardiovascular morbidity. Atherosclerosis, ischemic heart disease, hypertension, cardiomyopathy and arrhythmias. Scand J. Work Environ. Health, 10(6):381–388.
Landgrin, P.J., Baker, E., Whitworth, R., Feldman, R.G., 1980. Biochemistry of Ultra Trace Elements In: Needleman, H.L. (Ed.), Low Lead Exposure, the Clinical Implementation of Current Research. Plenum Press, New York and London, p.17.
Louekari, K., Valkonen, S., Pousi, S., Virtanen, L., 1991. Estimated dietary intake of lead and their concentration in blood. Sci. Total Environ., 105:87–99. [doi:10.1016/0048-9697(91)90331-8]
McMichael, A.J., Johnson, H.M., 1982. Long-term mortality profile of heavily exposed lead smelter workers. J. Occup. Med., 24:375–378.
Muntner, P., He, J., Vupputuri, S., Coresh, J., Batuman, V., 2003. Blood lead and chronic kidney disease in the general United States population, results from NHANES III. Kidney Int., 63(3):1044–1050. [doi:10.1046/j.1523-1755.2003.00812.x]
Nixon, D.E., 1996. Routine clinical determination of lead, arsenic, cadmium and thallium in urine and whole blood by inductively coupled plasma mass spectrometry. Spectrochim. Acta, 51B(1):13–25.
Pocock, S.J., Shaper, A.G., Ashby, D., Delves, I., 1984. Blood lead concentration, blood pressure, and renal function. Br. Med. J., 289:872–874.
Rifai, N., Bachorik, P.S., Albers, J., Tietz, J., 1999. Textbook of Clinical Chemistry, 3rd Ed. W.B. Saunders Company, Philadelphia, p.809–861.
Shang, S., Hang, W., 1997. Flame atomic absorption spectrometry using micro volume injection technique for the determination of Cu, Zn, Ca, Mg and Fe in whole blood from healthy infant and mother ears. Fresenius. J. Anal. Chem., 357(7):997–999. [doi:10.1007/s002160050290]
Stephen, M., 2001. Current Medical Diagnosis and Treatment, 40th Ed. Lawrence Tierney, McGraw Hill Company, USA.
Subramanian, K.S., Meranger, J.C., 1983. Blood levels of cadmium, copper, lead and zinc in children in a British Columbia community. Sci. Total Environ., 30:231–244. [doi:10.1016/0048-9697(83)90015-3]
Xilei, L., Renterghem, V., Cornelis, R., Mees, L., 1988. Radiochemical neutron activation analysis for thirteen trace metals in human blood serum by using inorganic ion exchange. Anal. Chim. Acta, 211(1):231–241. [doi:10.1016/S0003-2670(00)83683-1]
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Rahman, S., Khalid, N., Zaidi, J.H. et al. Non-occupational lead exposure and hypertension in Pakistani adults. J. Zhejiang Univ. - Sci. B 7, 732–737 (2006). https://doi.org/10.1631/jzus.2006.B0732
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DOI: https://doi.org/10.1631/jzus.2006.B0732