Relationship between genetic variation in the α2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population
There are differences in individual cardiovascular responses to the administration of dexmedetomidine, a highly selective α2A-adrenergic receptor (ADRA2A) agonist. The aim of this study was to investigate ADRA2A gene polymorphisms in the Chinese Han population and their association with the cardiovascular response to intravenous dexmedetomidine infusion. Sixty elective surgery patients of Chinese Han nationality were administered 1 µg/kg dexmedetomidine intravenously over 10 min as a premedication. ADRA2A C-1291G and A1780G polymorphism status was determined in these patients, and their relationships to changes in blood pressure and heart rate after dexmedetomidine administration were analyzed. There were neither significant differences in systolic or diastolic blood pressure changes in individuals with different A1780G and C-1291G genotypes after dexmedetomidine administration, nor in heart rates among the different A1780G genotypes. However, there were significant differences in changes in heart rates in patients with different C-1291G genotypes. There were no significant differences in the sedative effects of dexmedetomidine among different A1780G and C-1291G genotypes. Logistic regression revealed that the C-1291G polymorphism was associated with differential decreases in heart rate after intravenous infusion of dexmedetomidine. These findings indicate that the ADRA2A C-1291G polymorphism can affect heart rate changes in patients after intravenous infusion of dexmedetomidine.
Key wordsDexmedetomidine a2A-Adrenergic receptor Polymorphism Blood pressure Heart rate
目的: 通过对右美托咪定静脉输注的临床研究,评价中国汉族人群中肾上腺素α2A 受体基因多态性与右美托咪定心血管效应的相关性。
创新点: 探索右美托咪定的心血管系统反应与肾上腺素α2A 受体基因多态性的关系,期望为临床个体化 应用右美托咪定及其他α2 受体激动剂提供重要 的依据。
方法: 本研究取得单位伦理委员会的批准,所有受试者 告知受试内容并签署知情同意书。60 例美国麻醉 医师协会I–II 行择期手术汉族患者根据标准入选 本研究。通过静脉输注右美托咪定,记录收缩压、 舒张压、心率等心血管效应数据,并用聚合酶链 式反应(PCR)法检测ADRA2A2A 基因单核苷酸多 态性。
结论: 中国汉族人群中肾上腺素α2A 受体C-1291G 基因 多态性与应用右美托咪定后心率变化有相关性。
关键词右美托咪定 肾上腺素α2A 受体 多态性 血压 心率
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