Journal of Zhejiang University-SCIENCE B

, Volume 20, Issue 4, pp 300–309 | Cite as

Simulation of inter atrial block based on a human atrial model

  • Yuan Gao
  • Ying-lan Gong
  • Ling XiaEmail author
  • Ding-chang Zheng


Inter atrial block (IAB) is a prevailing cardiac conduction abnormality that is under-recognized in clinical practice. IAB has strong association with atrial arrhythmia, left atrial enlargement, and electromechanical discordance, increasing the risk of atrial fibrillation (AF) and myocardial ischemia. IAB was generally believed to be caused by impaired conduction along the Bachmann bundle (BB). However, there are three other conduction pathways, including the fibers posteriorly in the vicinity of the right pulmonary veins (VRPV), transseptal fibers in the fossa ovalis (FO), and muscular bundles on the inferior atrial surface near the coronary sinus (CS). We hypothesized that the importance of BB on IAB might have been overestimated. To test this hypothesis, various combinations of conduction pathway blocks were simulated based on a realistic human atrial model to investigate their effects on the index of clinical diagnosis standard of IAB using a simulated 12-lead electrocardiogram (ECG). Firstly, the results showed that the BB block alone could not generate typical P wave morphology of IAB, and that the combination of BB and VRPV pathway block played important roles in the occurrence of IAB. Secondly, although single FO and CS pathways play subordinate roles in inter atrial conduction, their combination with BB and VRPV block could also produce severe IAB. In summary, this simulation study has demonstrated that the combinations of different inter atrial conduction pathways, rather than BB alone, resulted in ECG morphology of IAB. Attention needs to be paid to this in future pathophysiological and clinical studies of IAB.

Key words

Inter atrial block Electrocardiogram Simulation Heart model 


概 要

目 的

探究不同心房间传导通道阻滞的组合对形成房间 阻滞的影响及体表心电图变化, 探究房间阻滞的 产生机理。


通过仿真证明了单一Bachmann 束阻滞并不能产 生典型的房间阻滞P 波时长和波形, 并结合电兴 奋传导时序, 解 了房间阻滞的产生机理。

方 法

通过 64 位螺旋电子计算机断层扫描 (CT) 扫描 人体心房, 构建心房解剖模型。阻断不同的心房 间传导通道, 以单域方程仿真出心房电兴奋传导 时序, 采用边界元法计算各时刻人体体表电位, 进而计算出 P 波波形。

结 论

要使 P 波时长和形态均满足临床诊断房间阻滞的 条件, 必须同时阻断 Bachmann 束和右肺静脉后 部的穿间隔纤维 (VRPV) 通道, 这为进一步了解 房间阻滞的发病机制及未来临床研究提供了指导。


房间阻滞 心电图 仿真 心脏建模 

CLC number



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Copyright information

© Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical EngineeringZhejiang UniversityHangzhouChina
  2. 2.Health and Wellbeing Academy, Faculty of Medical ScienceAnglia Ruskin UniversityChelmsfordUK

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