Journal of Zhejiang University-SCIENCE B

, Volume 19, Issue 8, pp 643–653 | Cite as

Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults

  • Shao-wei XueEmail author
  • Tien-wen Lee
  • Yong-hu Guo


Medial orbitofrontal cortex (mOFC) abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging (R-fMRI) study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample (NKI-RS) to examine the relationship between the fractional amplitude of low-frequency fluctuation (fALFF) signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity (RSFC) between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.

Key words

Trait anxiety Fractional amplitude of low-frequency fluctuation (fALFF) Medial orbitofrontal cortex Precuneus Functional connectivity 






采用Louvain 网络模块检测方法对大脑内侧眶额进行自动化功能亚区分割,并发现内侧眶额与健康成年男性特质型焦虑的关系。






特质型焦虑 低频振幅比率 内侧眶额 楔前叶 功能连通性 

CLC number



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Copyright information

© Zhejiang University and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institutes of Psychological SciencesHangzhou Normal UniversityHangzhouChina
  2. 2.Center for Cognition and Brain DisordersHangzhou Normal UniversityHangzhouChina
  3. 3.Zhejiang Key Laboratory for Research in Assessment of Cognitive ImpairmentsHangzhouChina
  4. 4.Department of PsychiatryDajia Lee’s General Hospital, Lee’s Medical CorporationTaichungChina

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