Time Interval and Continuous Testing of Stimuli Responsive Hydrogels


Researchers have investigated hydrogels as potential materials for biological monitoring. Hydrogel compositions have been designed to respond to changes in temperature, pH, glucose concentration and ionic strength concentration. Hydrogels designed to respond to changes in environmental conditions have demonstrated their ability to respond via a swelling or shrinking action. This swelling behavior can be exploited using a variety of signal transduction methods. While this technology shows promise, the degradation of hydrogel materials has not yet been characterized with respect to the shelf life of hydrogel samples or to their use in continuous testing. A series of experiments were performed to test hydrogels stored for extended periods of time then subjected to oscillatory testing, and the results have been analyzed to determine whether hydrogels can be used for extended periods of time for biological sensing applications.

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  1. 1.

    S. K. De, N. R. Aluru, B. Johnson, W. C. Crone, D. J. Beebe, J. Moore, Equilibrium swelling and kinetics of pH-responsive hydrogels: models, experiments and simulations, Journal of Microelectromechanical Systems 11 (2002) 544–555.

    CAS  Article  Google Scholar 

  2. 2.

    P. W. Bienes, I. Klosterkamp, B. Menges, U. Jonas, W. Knoll, Responsive thin hydrogel layers from photo-cross-linkable poly (N-isopropylacrylamide) terpolymers, Langmuir 23 (2007) 2231–2238.

    Article  Google Scholar 

  3. 3.

    M. Liu, T. Guo, Preparation and swelling properties of crosslinked sodium polyacrylate, Journal of Applied Polymer Science 82 (2001) 1515–1520.

    CAS  Article  Google Scholar 

  4. 4.

    D. Kuckling, J. Hoffman, M. Plotner, D. Ferse, K. Kretschmer, H. P. Adler, K. Arndt, R. Reichelt, Photo cross-linkable poly(N-isopropylacrylamide) copolymers III: micro-fabricated temperature responsive hydrogels, Polymer 44 (2003) 4455–4462.

    CAS  Article  Google Scholar 

  5. 5.

    J. Shin, P. V. Braun, W. Lee, Fast responsive photonic crystal pH sensor based on template photo-polymerized hydrogel inverse opal, Sensors and Actuators B: Chemical 150 (2010) 183–190.

    CAS  Article  Google Scholar 

  6. 6.

    T. Iwata, K. Suzuki, N. Amaya, H. Higuchi, H. Masunaga, S. Sasaki, H. Kikuchi, Control of cross-linking polymerization kinetics and polymer aggregated structure in polymer-stabilized liquid crystalline blue phases, Macromolecules 42 (2009) 2002–2008.

    CAS  Article  Google Scholar 

  7. 7.

    I. Y. Galeav, B. Mattiason, Smart polymers and what they could do in biotechnology and medicine, Trends in Biotechnology 17 (1999) 335–340.

    Article  Google Scholar 

  8. 8.

    J.S. Bates, S.H. Cho, P. Tathireddy, L.W. Rieth, J.J. Magda, Smart Hydrogels Designed for Used in Microfabricated Sensor Arrays, MRS Proceedings 1570 (2013) 1–6

    Article  Google Scholar 

  9. 9.

    G. Lin, S. Chang, C.-H. Kuo, J. Magda, F. Solzbacher, Free swelling and confined smart hydrogels for applications in chemomechanical sensors for physiological monitoring, Sensors and Actuators B: Chemical 136 (2009) 186–195.

    CAS  Article  Google Scholar 

  10. 10.

    V. Schulz, M. Guenther, G. Gerlach, J. J. Magda, P. Tathireddy, L. Rieth, F. Solzbacher, In-vitro investigations of a pH- and ionic-strength-responsive polyelectrolyte hydrogel using a piezoresistive microsensor, Smart Struct Mater Nondestruct Eval Health Monitor Diagn 7827 (2009) 1–16.

    Google Scholar 

  11. 11.

    G. Gerlach, M. Guenther, J. Sorber, G. Suchanek, Chemical and pH sensors based on the swelling behavior of hydrogels, Sensors and Actuators B 111 (2005) 555–561.

    Article  Google Scholar 

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Bates, J.S., Magda, J.J. Time Interval and Continuous Testing of Stimuli Responsive Hydrogels. MRS Online Proceedings Library 1622, 153–159 (2013). https://doi.org/10.1557/opl.2014.7

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