End-stage renal disease (ESRD) is a life-threatening illness that presents significant healthcare challenges. About 90% of ESRD patients receive hemodialysis treatment, but the currently available hemodialysis systems are bulky and prone to complications. We report the design of a microfluidic hemodialysis device composed of two polydimethylsiloxane (PDMS) chambers separated by a cellulose ester (CE) membrane. The polyethylene glycol-passivated PDMS and CE surfaces reduced platelet adhesion by 74% and 86%, respectively. Moreover, the device exhibited a higher urea clearance rate per unit area than a healthy kidney. The reported design sets the foundation for a next-generation biomimetic portable hemodialysis device.
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Ausri, I.R., Feygin, E.M., Cheng, C.Q. et al. A highly efficient and antifouling microfluidic platform for portable hemodialysis devices. MRS Communications 8, 474–479 (2018). https://doi.org/10.1557/mrc.2018.43