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High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the controlled release of curcumin

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Abstract

The aim of current study is to fabricate implantable curcumin embedded gelatin/polylactic acid/curcumin (GL/PLA/Cur) aligned fiber scaffolds by forcespinning®, which might have a potential application in drug delivery and cancer therapy. Fourier Transform Infrared Spectroscopy reveals the hydrogen bonding interactions between GL, PLA, and curcumin. In vitro curcumin drug release from GL/PLA/Cur fiber scaffolds is investigated and sustained release is observed over 15 days. Further, cell viability assay reveals that GL/PLA/Cur aligned fibers show excellent growth of human fibroblast cells. These results strongly suggest that the curcumin bearing GL/PLA/Cur composite fibers may show the potential application in cancer therapy, drug delivery, and wound dressing.

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Acknowledgments

The authors acknowledge the financial support from the Consejo Nacional de Ciencia y Tecnologia de Mexico (CONACyT), Project Number 242269.

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Authors and Affiliations

  1. Tecnológico de Monterrey, Campus Monterrey, School of Engineering and Science, Eugenio Garza Sada 2501 Sur, Col Tecnológico C.P., 64849, Monterrey, Nuevo León, México

    Narsimha Mamidi

  2. Tecnológico de Monterrey, Centro de Biotecnología-FEMSA, School of Engineering and Science, Av. Eugenio Garza Sada 2501, Monterrey, N.L., C.P. 64849, México

    Irasema Lopez Romo

  3. Department of Materials Science and NanoEngineering, Rice University, Houston, TX, 77005, USA

    Enrique V. Barrera

  4. Department of Chemistry, Rice University, Houston, TX, 77005, USA

    Alex Elías-Zúñiga

Authors
  1. Narsimha Mamidi
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  2. Irasema Lopez Romo
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  3. Enrique V. Barrera
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  4. Alex Elías-Zúñiga
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Correspondence to Narsimha Mamidi.

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Mamidi, N., Romo, I.L., Barrera, E.V. et al. High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the controlled release of curcumin. MRS Communications 8, 1395–1403 (2018). https://doi.org/10.1557/mrc.2018.193

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  • DOI: https://doi.org/10.1557/mrc.2018.193

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