High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the controlled release of curcumin

Abstract

The aim of current study is to fabricate implantable curcumin embedded gelatin/polylactic acid/curcumin (GL/PLA/Cur) aligned fiber scaffolds by forcespinning®, which might have a potential application in drug delivery and cancer therapy. Fourier Transform Infrared Spectroscopy reveals the hydrogen bonding interactions between GL, PLA, and curcumin. In vitro curcumin drug release from GL/PLA/Cur fiber scaffolds is investigated and sustained release is observed over 15 days. Further, cell viability assay reveals that GL/PLA/Cur aligned fibers show excellent growth of human fibroblast cells. These results strongly suggest that the curcumin bearing GL/PLA/Cur composite fibers may show the potential application in cancer therapy, drug delivery, and wound dressing.

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Acknowledgments

The authors acknowledge the financial support from the Consejo Nacional de Ciencia y Tecnologia de Mexico (CONACyT), Project Number 242269.

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Correspondence to Narsimha Mamidi.

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Mamidi, N., Romo, I.L., Barrera, E.V. et al. High throughput fabrication of curcumin embedded gelatin-polylactic acid forcespun fiber-aligned scaffolds for the controlled release of curcumin. MRS Communications 8, 1395–1403 (2018). https://doi.org/10.1557/mrc.2018.193

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