The goal of this study was to perform in situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in peripheral nerves to create a soft, precisely located injectable conductive polymer electrode for bi-directional communication. Intraneural PEDOT polymerization was performed to target both outer and inner fascicles via custom fabricated 3D printed cuff electrodes and monomer injection strategies using a combination electrode-cannula system. Electrochemistry, histology, and laser light sheet microscopy revealed the presence of PEDOT at specified locations inside of peripheral nerve. This work demonstrates the potential for using in situ PEDOT electrodeposition as an injectable electrode for recording and stimulation of peripheral nerves.
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This work was sponsored by the Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) Targeted Neural Plasticity (TNT) program under the auspices of Drs. Doug Weber and Tristan McClure-Begley through the DARPA Contracts Management Office: No. HR0011-17-2-0019 and the National Science Foundation (NSF CMMI—1739318).
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Murbach, J.M., Currlin, S., Widener, A. et al. In situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) for peripheral nerve interfaces. MRS Communications 8, 1043–1049 (2018). https://doi.org/10.1557/mrc.2018.138