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Engineered 2D nanomaterials–protein interfaces for efficient sensors

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Abstract

This article features the importance of nanomaterial–protein interfaces, with a special interest on two-dimensional (2D) nanomaterials, for next generation sensors and electronics. Graphene, the first isolated and studied 2D nanomaterial, is taken as the material of most interest and then focused on its engineering by heteroatom doping. The success of graphene engineering for sensors widened the search for better and efficient biosensor platforms of other layered materials such as boron nitride and transition metal dichalcogenides. But functionalization of 2D backbones with biomolecules often ends up with the disruption of the biological activities due to various reasons. This has to be fundamentally studied and corrected for the clinical implementation of these materials based novel sensing platforms in point-of-care devices and micro-fluidic chips. At the end, importance of various 2D materials–biomolecule interfaces is discussed, and MoS2 based label-free biosensor is highlighted. A method for the modification of MoS2–biomolecule interaction via covalent functionalization of oxygen functionalities in MoS2 is also proposed.

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ACKNOWLEDGMENTS

K.K.T. and T.N.N. acknowledge TIFR-Centre for Interdisciplinary Sciences (TCIS), Hyderabad, India for the financial support. V.R. and S.V. acknowledge Rothschild Foundation for support of our research.

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Authors and Affiliations

  1. TIFR-Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad, Telangana, 500 075, India

    Kiran Kumar Tadi & Tharangattu N. Narayanan

  2. Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas, 77251-1892, USA

    Sivaram Arepalli

  3. Department of Electrical and Computer Engineering, University of California, Santa Barbara, California, 93106-9560, USA

    Kaustav Banerjee

  4. Newton Wellesley Hospital, Newton, Massachusetts, 02462, USA

    Sowmya Viswanathan

  5. Department of Bioengineering, University of California, Berkeley, California, 94720-1762, USA

    Dorian Liepmann

  6. Department of Materials Science and Nanoengineering, Rice University, Houston, Texas, 77005-1892, USA

    Pulickel M. Ajayan

  7. Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Venkatesan Renugopalakrishnan

  8. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, 02115, USA

    Venkatesan Renugopalakrishnan

Authors
  1. Kiran Kumar Tadi
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  2. Tharangattu N. Narayanan
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  3. Sivaram Arepalli
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  4. Kaustav Banerjee
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  5. Sowmya Viswanathan
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  6. Dorian Liepmann
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  7. Pulickel M. Ajayan
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  8. Venkatesan Renugopalakrishnan
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Corresponding authors

Correspondence to Tharangattu N. Narayanan or Venkatesan Renugopalakrishnan.

Additional information

This paper has been selected as an Invited Feature Paper.

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Tadi, K.K., Narayanan, T.N., Arepalli, S. et al. Engineered 2D nanomaterials–protein interfaces for efficient sensors. Journal of Materials Research 30, 3565–3574 (2015). https://doi.org/10.1557/jmr.2015.349

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  • DOI: https://doi.org/10.1557/jmr.2015.349

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