One-pot solvothermal method to prepare functionalized Fe3O4 nanoparticles for bioseparation


Surface-functionalized magnetic nanoparticles were prepared by a facile one-pot solvothermal method in ethylene glycol solution. Zeta value, size, and magnetic properties could be well tuned by introducing different functional group molecules. Characterizations, including transmission electronic microscopy, scanning electronic microscopy, thermogravimetric analysis, x-ray powder diffraction and vibrating sample magnetometer, and Fourier transform infrared spectrophotometer demonstrated the efficiency of this simple and general synthesis strategy. The hydrophilic magnetic nanoparticles with various surface functional groups and zeta values were evidenced as excellent candidates for bioseparation by extracting DNA molecules from a model mixture of cell fractures.

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This work was supported by National Natural Science Foundation of China, the Foundation for Authors of National Excellent Doctoral Dissertations of People’s Republic of China, the Program for New Century Excellent Talents in Universities, the 973 Program (2011CBA00503, 2011CB932403), the National Transgenic Major Program (2008ZX08012-001), and the Fundamental Research Funds for the Central Universities.

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Correspondence to Guoxin Zhang or Xiaoming Sun or Tianwei Tan.

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Zhang, G., Qie, F., Hou, J. et al. One-pot solvothermal method to prepare functionalized Fe3O4 nanoparticles for bioseparation. Journal of Materials Research 27, 1006–1013 (2012).

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