Facile preparation of hydrophilic sodium yttrium fluoride nanorods using hydrophobic nanospheres as precursor


Synthesis of well-defined sodium yttrium fluoride (NaYF4) nanocrystals has been achieved in nonpolar solvents, but these nanocrystals possess a hydrophobic surface and need to be surface-modified for various biological applications. Development of facile aqueous solution method to synthesize one-dimensional NaYF4 with a hydrophilic surface still remains challenging. Herein, we demonstrate a simple route to prepare hydrophilic NaYF4 nanorods by using hydrophobic NaYF4 nanospheres as precursor. It is interesting to find that hydrothermal treatment of oleic acid-capped NaYF4 nanocrystals can not only induce anisotropic growth of these nanocrystals but also change their surface properties. The hydrophilic NaYF4 nanorods synthesized in this work has been well characterized and possible formation mechanism has also been discussed.

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  1. 1.

    F. Wang and X.G. Liu: Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. Chem. Soc. Rev. 38, 976 (2009).

    CAS  Article  Google Scholar 

  2. 2.

    J. Zhou, Z. Liu, and F.Y. Li: Upconversion nanosphosphors for small-animal imaging. Chem. Soc. Rev. 41, 1323 (2012).

    CAS  Article  Google Scholar 

  3. 3.

    D.K. Chatterjee, M.K. Gnanasammandhan, and Y. Zhang: Small upconverting fluorescent nanoparticles for biomedical applications. Small 6, 2781 (2011).

    Article  Google Scholar 

  4. 4.

    C.X. Li and J. Lin: Rare earth fluoride nano-/microcrystals: Synthesis, surface modification and application. J. Mater. Chem. 20, 6831 (2010).

    CAS  Article  Google Scholar 

  5. 5.

    D.K. Chatterjee, A.J. Rufalhah, and Y. Zhang: Upconversion fluorescence imaging of cells and small animals using lanthanide-doped nanocrystals. Biomaterials 29, 937 (2008).

    CAS  Article  Google Scholar 

  6. 6.

    M. Nyk, R. Kumar, T.Y. Ohulchanskyy, E.J. Bergey, and P.N. Prasad: High contrast in vitro and in vivo photoluminescence bioimaging using near-infrared to near-infrared upconversion in Tm3+ and Yb3+-doped fluoride nanosphosphors. Nano Lett. 8, 3834 (2008).

    CAS  Article  Google Scholar 

  7. 7.

    N.M. Idris, Z.Q. Li, L. Ye, E.K.W Sim, R. Mahendran, P.C.L Ho, and Y. Zhang: Tracking transplanted cells in live animal using upconversion fluorescent nanoparticles. Biomaterials 30, 5104 (2009).

    CAS  Article  Google Scholar 

  8. 8.

    L.Q. Xiong, T.S. Yang, Y. Yang, C.J. Xu, and F.Y. Li: Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors. Biomaterials 31, 7078 (2010).

    CAS  Article  Google Scholar 

  9. 9.

    G.F. Wang, Q. Peng, and Y.D. Li: Lanthanide-doped nanocrystals: synthesis, optical-magnetic properties and applications. Acc. Chem. Res. 44, 322 (2011).

    Article  Google Scholar 

  10. 10.

    J. Shen, L.D. Sun, and C.H. Yan: Luminescent rare earth nanomaterials for bioprobe applications. Dalton Trans. 42, 5687 (2008).

    Article  Google Scholar 

  11. 11.

    L.Y. Wang, R.X. Yan, Z.Y. Hao, L. Wang, J.H. Zeng, H. Bao, X. Wang, Q. Peng, and Y.D. Li: Fluorescence resonant energy transfer biosensor based on upconversion-luminescent nanoparticles. Angew. Chem. Int. Ed. 44, 6054 (2005).

    CAS  Article  Google Scholar 

  12. 12.

    J.L. Liu, Y. Liu, Q. Liu, C.Y. Li, L.N. Sun, and F.Y. Li: Iridium(III) complex-coated nanosystem for ratiometric upconversion luminescence bioimaging of cyanide anions. J. Am. Chem. Soc. 133, 15276 (2011).

    CAS  Article  Google Scholar 

  13. 13.

    H.X. Mai, Y.W. Zhang, R. Si, Z.G. Yan, L.D. Sun, L.P. You, and C.H. Yan: High-quality sodium rare-earth fluoride nanocrystals: Controlled synthesis and optical properties. J. Am. Chem. Soc. 128, 6426 (2006).

    CAS  Article  Google Scholar 

  14. 14.

    L.Y. Wang and Y.D. Li: Controlled synthesis and luminescence of lanthanide-doped NaYF4 nanocrystals. Chem. Mater. 19, 727 (2007).

    CAS  Article  Google Scholar 

  15. 15.

    Z.Q. Li and Y. Zhang: An efficient and user-friendly method for the synthesis of hexagonal phase NaYF4:Yb, Er/Tm nanocrystals with controllable shape and upconversion fluorescence. Nanotechnology 19, 345606 (2008).

    Article  Google Scholar 

  16. 16.

    Z.G. Chen, H.L. Chen, H. Hu, M.X. Yu, F.Y. Li, Q. Zhang, Z.G. Zhou, Y. Tao, and C.H. Huang: Versatile synthesis strategy for carboxylic acid-functionalized upconverting nanosphosphor as biological labels. J. Am. Chem. Soc. 130, 3023 (2011).

    Article  Google Scholar 

  17. 17.

    Z.Q. Li, Y. Zhang, and S. Jiang: Multicolor core/shell-structured upconversion fluorescent nanoparticles. Adv. Mater. 20, 4765 (2008).

    CAS  Article  Google Scholar 

  18. 18.

    G.S. Yi, H.C. Lu, S.Y. Zhao, G. Yue, W.J. Yang, D.P. Chen, and L.H. Guo: Synthesis, characterization, and biological application of size-controlled nanocrystalline NaYF4:Yb, Er infrared-to-visible upconversion phosphors. Nano Lett. 4, 2191 (2004).

    CAS  Article  Google Scholar 

  19. 19.

    J.H. Zeng, J. Su, Z.H. Li, R.X. Yan, and Y.D. Li: Synthesis and upconversion luminescence of hexagonal-phase NaYF4:Yb, Er3+ phosphors of controlled size and morphology. Adv. Mater. 17, 2119 (2005).

    CAS  Article  Google Scholar 

  20. 20.

    C.X. Li, C.M. Zhang, Z.Y. Hou, L.L. Wang, Z.W. Quan, H.Z. Lian, and J. Lin: beta-NaYF4 and beta-NaYF4:Eu3+ microstructures: Morphology control and tunable luminescence properties. J. Phys. Chem. C 113, 2332 (2009).

    CAS  Article  Google Scholar 

  21. 21.

    J. Olesiak-Banska, M. Nyk, D. Kaczmarek, K. Matczyszyn, K. Pawlik, and M. Samoc: Synthesis and optical properties of water-soluble fluoride nanosphosphors co-doped with Eu3+ and Tb3+. Opt. Mater. 33, 1419 (2011).

    CAS  Article  Google Scholar 

  22. 22.

    H.C. Zeng: Synthetic architecture of interior space for inorganic nanostructures. J. Mater. Chem. 16, 649 (2006).

    CAS  Article  Google Scholar 

  23. 23.

    C.Z. Wu and Y. Xie: Controlling phase and morphology of inorganic nanostructures originated from the internal crystal structure. Chem. Commun. 40, 5943 (2009).

    Article  Google Scholar 

  24. 24.

    S. Heer, K. Kompe, H.U. Gudel, and M. Haase: Highly efficient multicolor upconversion emission in transparent colloids of lanthanide-doped NaYF4 nanocrystals. Adv. Mater. 16, 2102 (2004).

    CAS  Article  Google Scholar 

  25. 25.

    L.P. Qian, D. Yuan, G.S. Yi, and G.M. Chow: Critical shell thickness and emission enhancement of NaYF4:Yb, Er/NaYF4/silica core/shell nanoparticles. J. Mater. Res. 24, 3559 (2009).

    CAS  Article  Google Scholar 

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The authors acknowledge financial support from National Nature Science Foundation of China (No. 20901068) and Zhejiang Qianjiang Talent Project (No. 2010R10028).

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Correspondence to Zhengquan Li.

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Supplementary material can be viewed in this issue of the Journal of Materials Research by visiting http://journals.cambridge.org/jmr.

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Tao, Q., Li, Z., Zeng, Y. et al. Facile preparation of hydrophilic sodium yttrium fluoride nanorods using hydrophobic nanospheres as precursor. Journal of Materials Research 27, 2101–2105 (2012). https://doi.org/10.1557/jmr.2012.177

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