Reaction and diffusion dynamics in a microfluidic format

Abstract

A novel microfluidic structure based on the electroosmotic guiding of reagent streams is presented that can be used as a fully adjustable diffusion based microreactor. The position and the width of two aqueous reactant streams entering a laminar-flow chamber can be controlled individually by changing the flow ratio of three parallel guiding streams containing buffer only. To control the intensity of product formation, the overlapping area between the diffusion regions of the two different reagent streams can be adjusted. This article describes the fabrication and experimental characterization of the device.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    Tüdos, A.J., Besselink, G.A.J., Schasfoort, R.B.M., “Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry”, Lab on a Chip, 2001, 1, 83–95

    Article  Google Scholar 

  2. 2.

    Stephen J. Haswell, Victoria Skelton, “Chemical and biochemical microreactors”, Trends in analytical chemistry, 2000, vol.19, no. 6

    Google Scholar 

  3. 3.

    Brody, J.P., Yager, P., Goldstein, R.E., Austin, R.H., “Biotechnology at low Reynolds numbers”, Biophysical Journal, 1996, 71, 3430–3441

    CAS  Article  Google Scholar 

  4. 4.

    B.H. Weigl, P. Yager, “Silicon-microfabricated diffusion-based optical chemical sensor”, Sensors and Actuators B, 1997, 38–39, 425–457

    Google Scholar 

  5. 5.

    Geert A.J. Besselink, Paul Vulto, Rob G.H. Lammertink, Stefan Schlautmann, Albert van der Berg, Wouter Olthuis, Gerahard H.M. Engbers and Richard B.M. Schasfoort, “Electroosmotic guiding of sample flows in a laminar flow chamber”, Electrophoresis, submitted 02.2004

    Google Scholar 

  6. 6.

    Charles N. Baroud, Fridolin Okkels, et. al., “Reaction-diffusion dynamics: Confrontation between theory and experiment in a microfluidic reactor”, Physical Review E, 2003, 67

  7. 7.

    Wensink, H., Elwenspoek, M.C., “Reduction of sidewall inclination and blast lag of powder blasted channels”, Sensors and Actuators A, 2002, 102, 157–164

    CAS  Article  Google Scholar 

  8. 8.

    K. Yunus a, C.B. Marks, et. al., “Hydrodynamic voltammetry in microreactors: multiphase flow”, Electrochemistry Communications”, 2002, 4, 579–583

    Article  Google Scholar 

Download references

Acknowledgments

The authors like to acknowledge the funding of this research by the “Netherlands Organization for Scientific Research” (NOW) as a part of the SPRINTLOC “vernieuwings impuls” project.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Dietrich Kohlheyer.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kohlheyer, D., Lammertink, R.G.H., Schlautmann, S. et al. Reaction and diffusion dynamics in a microfluidic format. MRS Online Proceedings Library 820, 79–84 (2004). https://doi.org/10.1557/PROC-820-O3.5

Download citation