Superparamagnetic Iron Oxide Nanoarticles for Biomedical Applications: a focus on PVA as a coating

Abstract

Nanoscaled particles showing a superparamagnetic behavior have been intensively studied these past years for biomedical applications and water-based ferrofluids turned out to be promising candidates for various in vivo as well as in vitro applications. Nevertheless, the lack of well-defined particles remains an important problem. One of the major challenges is still the large-scale synthesis of particles with a narrow size distribution. In this work iron oxide nanoparticles are obtained by classical co-precipitation in a water-based medium and are subsequently coated with polyvinyl alcohol. The thus obtained ferrofluids are studied and a focus is made on their colloidal stability.

References

  1. 1.

    Roger, J., Pons, J. N., Massart, R., Halbreich, A., Bacri, J. C. Eur. Phys. J. 5 (1999) 321

    CAS  Article  Google Scholar 

  2. 2.

    Lübbe, A. S., Bergemann, C., Brock, J., McClure D. G. J. Magn. and Magn. Mater. 194 (1999) 149

    Article  Google Scholar 

  3. 3.

    Taylor, J. I., Hurst, C. D., Davies, M. J., Sachsinger, N., Bruce, I. J. J. Chromatogr. A 890 (2000) 159

    CAS  Article  Google Scholar 

  4. 4.

    Jung, C. W., Jacobs, P. J. Magn. Reson. Imaging, 13 (1995) 661

    CAS  Article  Google Scholar 

  5. 5.

    Jung, C. W, Rogers, J. M., Groman, E. V. J. Magn. and Magn. Mater. 194 (1999) 210

    CAS  Article  Google Scholar 

  6. 6.

    Safarik, I., Safarikova, M., J. Chromatog. B 772 (1999) 33

    Article  Google Scholar 

  7. 7.

    Goodwin, S., Peterson, C., Hoh, C., Bittner, C. J. Magn. and Magn. Mater. 194 (1999) 132

    CAS  Article  Google Scholar 

  8. 8.

    Bergemann, C., Müller-Schulte, D., Oster, J., Brassard, L., Lübbe, A. S. J. Magn. and Magn. Mater. 194 (1999) 45

    CAS  Article  Google Scholar 

  9. 9.

    Sheng, R., Flores, G. A., Liu, J. J. Magn. and Magn. Mater. 194 (1999) 167

    CAS  Article  Google Scholar 

  10. 10.

    http://www.niams.nih.gov, National Institute of Arthritis and Muskulosceletal and Skin Diseases

  11. 11.

    Van Ewijk, G. A., Vroege, G. J., Philipse, A. P. J. Magn. and Magn. Mater. 201 (1999) 31

    Article  Google Scholar 

  12. 12.

    Submitted paper, M. Chastellain, A. Petri and H. Hofmann, J. Coll. and Interface Sc.

  13. 13.

    Massart, R., Cabuil, V. J. Chim. Physique 84 (1987) 967

    CAS  Article  Google Scholar 

  14. 14.

    J.-C. Bacri, R. Perzynski, D. Salin, V. Cabuil, R. Massart, J. Magn. and Magn. Mater. 62 (1986) 36

    CAS  Article  Google Scholar 

  15. 15.

    Li, H., Zhang, W., Xu, W., Zhang, X. Macromolecules 33 (2000) 465

    CAS  Article  Google Scholar 

  16. 16.

    Jolivet, J. -P., De la Solution à L'oxyde, CNRS Editions, Paris, 1994

    Google Scholar 

  17. 17.

    Paper to be submitted in collaboration with B. von Rechenberg (MSRU, Tierspital, Zürich, Switzerland)

  18. 18.

    Paper to be submitted in collaboration with L. Juillerat (CHUV, Lausanne, Switzerland)

Download references

Acknowledgments

Part of this work was funded by the European MAGNANOMED project (EC contract GRD5-CT2000-00375).

Author information

Affiliations

Authors

Corresponding author

Correspondence to M. Chastellain.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chastellain, M., Petri, A. & Hofmann, H. Superparamagnetic Iron Oxide Nanoarticles for Biomedical Applications: a focus on PVA as a coating. MRS Online Proceedings Library 789, 87–90 (2003). https://doi.org/10.1557/PROC-789-N11.21

Download citation