Covalently-linked Adducts of Single-walled Nanotubes with Biomolecules: Synthesis, Hybridization, and Biologically-Directed Surface Assembly

Abstract

Covalently-linked adducts of single-walled carbon nanotubes (SWNTs) with biomolecules have been fabricated. Results are presented here for DNA-SWNT and for biotin-SWNT adducts. DNA-SWNT adducts are shown to be biochemically accessible and to exhibit high selectivity, favoring hybridization with complementary vs. non-complementary DNA sequences. Biotin-SWNT adducts were also prepared and used to direct the assembly of nanotubes onto a biotinylated glass surface.

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Acknowledgments

The authors acknowledge helpful suggestions from Professors Eric Simanek, Robert M. Corn, Lloyd M. Smith, Richard Crooks, and Dr. Charles G. Fry. This work was sponsored by the National Science Foundation Grant #DMR-0210806, the Defense Advanced Research Projects Agency (DARPA) and the Air Force Research Laboratory, Air Force Materiel Command, USAF, under agreement number F30602-01-2-0555. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the National Science Foundation, the Defense Advanced Research Projects Agency (DARPA), the Air Force Research Laboratory, or the U.S. Government.

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Correspondence to Sarah E. Baker.

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Baker, S.E., Lasseter, T.L., Smith, L.M. et al. Covalently-linked Adducts of Single-walled Nanotubes with Biomolecules: Synthesis, Hybridization, and Biologically-Directed Surface Assembly. MRS Online Proceedings Library 737, 46 (2002). https://doi.org/10.1557/PROC-737-F4.6

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