Medical Applications of Water-Soluble Polyhydroxylated Fullerene Derivatives

Abstract

The promising positive results in reducing superoxide free radicals (O2), generated by in-vitro xanthine and xanthine oxidase, have been demonstrated in the evaluation of potential uses of novel water-soluble [60] fullerenols as free radical scavengers. Observation reveals the inherent application of fullerenols in a wide range of medical and clinical areas as preventive alternatives for a long-term medical treatment.

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References

  1. (1)

    For review of fullerene functionalization chemistry see: Taylor, R.; Walton, D. R. M. Nature 1993, 363, 685.

    CAS  Article  Google Scholar 

  2. (2)

    Krusic, P. J.; Wasserman, E.; Keizer, P. N.; Morton, J. R.; Preston, K. F. Science 1991, 254, 1183.

    CAS  Article  Google Scholar 

  3. (3)

    Chiang, L. Y.; Swirczewski, J. W.; Hsu, C. S.; Chowdhury, S. K.; Cameron, S.; Creegan, K. J. Chem. Soc, Chem. Commun. 1992, 1791.

    Google Scholar 

  4. (4)

    Chiang, L. Y.; Wang, L. Y.; Swirczewski, J. W.; Soled, S.; Cameron, S. J. Org. Chem. 1994, 59, 3960.

    CAS  Article  Google Scholar 

  5. (5)

    Chiang, L. Y.; Upasani, R. B.; Swirczewski, J. W. U.S. Patent 5,177,248, 1993; U.S. Patent 5,294,732, 1994.

  6. (6)

    Chiang, L. Y.; Lu, F. J.; Lin, J. T. to be published.

  7. (7)

    Friedman, S. H.; DeCamp, D. L.; Sijbesma, R. P.; Srdanov, G.; Wudl, F.; Kenyon, G. L. J. Am. Chem. Soc. 1993, 115, 6506.

    CAS  Article  Google Scholar 

  8. (8)

    Tokuyama, H.; Yamago, S.; Nakamura, E. J. Am. Chem. Soc. 1993, 115, 7918.

    CAS  Article  Google Scholar 

  9. (9)

    Chiang, L. Y.; Upasani, R. B.; Swirczewski, J. W. J. Am. Chem. Soc. 1992, 114, 10154.

    CAS  Article  Google Scholar 

  10. (10)

    Chiang, L. Y.; Upasani, R. B.; Swirczewski, J. W.; Soled, S. J. Am. Chem. Soc. 1993, 115, 5453.

    CAS  Article  Google Scholar 

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Correspondence to Long Y. Chiang.

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Chiang, L.Y., Lu, FJ. & Linc, JT. Medical Applications of Water-Soluble Polyhydroxylated Fullerene Derivatives. MRS Online Proceedings Library 359, 327–330 (1994). https://doi.org/10.1557/PROC-359-327

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