Collagenous Biocomposites for the Repair of Soft Tissue Injury


Results of implantation studies in a variety of animal tissue models demonstrate that the rate of biogradation of a collagen scaffold should parallel the rate of wound healing observed in particular anatomic sites. This rapid degradation maximizes tissue regeneration and minimizes encapsulation of the implant. The following paper reviews the effects of crosslinking on the rate of tissue ingrowth and regeneration. In addition, preliminary mechanical data on newly developed soluble type I collagen fibers is presented as a possible advance in the production of high strength collagen based tissue scaffolds.

This is a preview of subscription content, access via your institution.


  1. (1)

    D.E. Birk, F.H. Silver, and R.L. Trelstad, In: The Cell Biology of the Extracellular Matrix, 2nd ed. edited by E.D. Hay (Academic Press, N.Y., 1991) p. 221.

  2. (2)

    R.L.L. Collins, D Christiansen, G.A. Zazanis, and F.H. Silver, Journal of Biomedical Materials Research, 25, 267 (1991).

    CAS  Article  Google Scholar 

  3. (3)

    C.J. Doillon, C.F. Whyne, R.A. Berg, R.M. Olsen, and F.H. Silver, Scanning Electron Microscopy III, 1313 (1984).

    Google Scholar 

  4. (4)

    C.J. Doillon, C.F. Whyne, S. Brandwein, and F.H. Silver, Journal of Biomedical Materials Research, 20, pp 1219 (1986).

    CAS  Article  Google Scholar 

  5. (5)

    C.J. Doillon, and F.H. Silver, Biomaterials, Vol 7,3 (1986).

    CAS  Article  Google Scholar 

  6. (6)

    C. J. Doillon, F.H. Silver, and R.A. Berg, Biomaterials 8,195 (1987).

    CAS  Article  Google Scholar 

  7. (7)

    C.J. Doillon, A.J. Wasserman, R.A. Berg, and F.H. Silver, Biomaterials, 2,91 (1988).

    Article  Google Scholar 

  8. (8)

    C.J. Doillon, F.H. Silver, R.M. Olson, C.Y. Kamath, and R.A. Berg, Scanning Electron Microscopy, 2, No. 2,985 (1988).

    CAS  Google Scholar 

  9. (9)

    M.G. Dunn, A.J. Tria, Y.P. Kato, J.R. Bechler, R.S. Ochner, J.P. Zawadsky, and F.H. Silver, American Journal of Sports Medicine, In Press (1991).

    Google Scholar 

  10. (10)

    J.D. Goldstein, A.J. Tria, J.P. Zawadsky, Y.P. Kato, D. Christiansen, and F.H. Silver, Journal of Bone and Joint Surgery,71-A, No.8,1183 (1989).

    Article  Google Scholar 

  11. (11)

    Y.P. Kato, D.L. Christiansen, R.A. Hahn, S-J. Shieh, J.D. Goldstein, and F.H. Silver, Biomaterials, 10, 38 (1989).

    CAS  Article  Google Scholar 

  12. (12)

    Y.P. Kato, and F.H. Silver, Biomaterials, 11, 169 (1990).

    CAS  Article  Google Scholar 

  13. (13)

    Y.P. Kato, M.G. Dunn, J.P. Zawadsky, A.J. Tria, and F.H. Silver, Journal of Bone and Joint Surgery, 73-A, No.4, 561 (1991).

    Article  Google Scholar 

  14. (14)

    M.G. Marks, C.J. Doillon, and F.H. Silver, Journal of Biomedical Materials Research, 25, 683 (1991).

    CAS  Article  Google Scholar 

  15. (15)

    A.H. Rizvi, A.J. Wasserman, G. Zazanis, and F.H. Silver, Scanning Electron Microscopy, In press (1991).

    Google Scholar 

  16. (16)

    F.H. Silver, C.J. Doillon, B. Rojo, R.M. Olsen, C.Y. Kamath, and R.A. Berg Materials Research Society Symposium Proceedings, 110, 371 (1989).

    Article  Google Scholar 

  17. (17)

    K. Weadock, R.M. Olson, and F.H. Silver, Biomater. Med. Devices Artif. Organs, 11, 293 (1984).

    CAS  Article  Google Scholar 

  18. (18)

    E. Wong, D. Christiansen, A.H. Rizvi, H.M. Geller, and F.H. Silver, Journal of Applied Biomaterials Vol. 1, 225 (1990).

    Article  Google Scholar 

  19. (19)

    I.V. Yannas, D.P. Orgill, J. Silver, T.V. Norregaard, N.T. Zervas, and W.C. Schoene, In: Advances in Biomedical Polymers (Plenum Press, N.Y., 1987) p. 1.

    Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Christiansen, D., Pins, G., Wang, M.C. et al. Collagenous Biocomposites for the Repair of Soft Tissue Injury. MRS Online Proceedings Library 252, 151–158 (1991).

Download citation