Collagenous Biocomposites for the Repair of Soft Tissue Injury

MRS Online Proceedings Library volume 252, pages151–158(1991)Cite this article

Abstract

Results of implantation studies in a variety of animal tissue models demonstrate that the rate of biogradation of a collagen scaffold should parallel the rate of wound healing observed in particular anatomic sites. This rapid degradation maximizes tissue regeneration and minimizes encapsulation of the implant. The following paper reviews the effects of crosslinking on the rate of tissue ingrowth and regeneration. In addition, preliminary mechanical data on newly developed soluble type I collagen fibers is presented as a possible advance in the production of high strength collagen based tissue scaffolds.

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Affiliations

  1. Dept. of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ., 08854, USA

    David Christiansen, George Pins, Ming Che Wang & Frederick H. Silver

  2. Orthopaedic Research Laboratory, Division of Orthopaedic Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA

    Michael G. Dunn

Authors
  1. David Christiansen
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  2. George Pins
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  3. Ming Che Wang
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  4. Michael G. Dunn
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  5. Frederick H. Silver
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Christiansen, D., Pins, G., Wang, M.C. et al. Collagenous Biocomposites for the Repair of Soft Tissue Injury. MRS Online Proceedings Library 252, 151–158 (1991). https://doi.org/10.1557/PROC-252-151

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