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Multivalent Biomimetic Glyconanoparticle Platforms as QCM Amplifiers for Lectin-Carbohydrate Interactions

MRS Online Proceedings Library volume 1257, Article number: 708 (2010) Cite this article

Abstract

The Lectin-Carbohydrate interaction was investigated by combining the Quartz Crystal Microbalance-QCM technique with signal amplifying biomimetic nanoparticle-NP platforms. A library of glyconanoparticles was prepared and the avidity of these NPs for immobilised lectin layers was then evaluated by a QCM setup. Large responses were observed as a result of surface recognition by nanoparticles displaying the appropriate molecular functionality. Large affinity enhancements were also in evidence due to the biomimetic nature of the glyconanoparticle assemblies’ carbohydrate presentation demonstrating evidence of the cluster glycoside effect.

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Affiliations

  1. Adaptative Supramolecular Nanosystems Group, Institut Européen des Membranes, UMR-CNRS-5635, IEM/UMII, Place Eugène Bataillon CC047, 34095, Montpellier cedex, France

    Eugene Mahon & Mihail Barboiu

  2. Attana AB, Björnnäsvägen 21, S-11347, Stockholm, Sweden

    Teodor Aastrup

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  1. Eugene Mahon
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  2. Teodor Aastrup
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  3. Mihail Barboiu
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Correspondence to Mihail Barboiu.

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Mahon, E., Aastrup, T. & Barboiu, M. Multivalent Biomimetic Glyconanoparticle Platforms as QCM Amplifiers for Lectin-Carbohydrate Interactions. MRS Online Proceedings Library 1257, 708 (2010). https://doi.org/10.1557/PROC-1257-O07-08

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