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In vivo degradation behavior of PDC multiblock copolymers containing poly(p-dioxanone) hard segments and crystallizable poly(ε-caprolactone) switching segments

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Abstract

The degradation behavior of biodegradable multiblock copolymers (PDC) containing poly(p-dioxanone) hard segments (PPDO) and crystallizable poly(s-caprolactone) switching segments (PCL) synthesized via co-condensation of two oligomeric macrodiols with an aliphatic diisocyanate as junction unit was explored in in vivo and in vitro experiments. The in vitro experiments for enzymatic degradation resulted that the poly(s-caprolactone) segments are degraded faster, than the poly(p-dioxanone) segments. During degradation the outer layer of the test specimen becomes porous. Finally non-soluble degradation products in form of particles were found at the surface. This observation is in good agreement with the in vivo studies, where the non-soluble degradation products in the periimplantary tissues showed a diameter of 1–3 micron.

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Acknowledgments

Authors are grateful to the German Federal Ministry of Education and Research for providing financial support within the BioFuture Award No. 0311867.

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Authors and Affiliations

  1. Center for Biomaterial Development, Institute of Polymer Research, GKSS Research Center, Kantstrasse 55, D-14513, Teltow, Germany

    B. Hiebl, K. Kratz, F. Jung, A. Lendlein & R-P. Franke

  2. Berlin-Brandenburg-Center for Regenerative Therapies, Charité- Universitätsmedizin Berlin_BCRT, Campus Virchow-Klinikum, Augustenburger Platz 1, D-13353, Berlin, Germany

    B. Hiebl, K. Kratz, F. Jung, A. Lendlein & R-P. Franke

  3. Department of Biomaterials, University of Ulm, Central Institute for Biomedical Engineering, Ulm, Germany

    R. Fuhrmann & R-P. Franke

Authors
  1. B. Hiebl
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  2. K. Kratz
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  3. R. Fuhrmann
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  4. F. Jung
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  5. A. Lendlein
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  6. R-P. Franke
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Hiebl, B., Kratz, K., Fuhrmann, R. et al. In vivo degradation behavior of PDC multiblock copolymers containing poly(p-dioxanone) hard segments and crystallizable poly(ε-caprolactone) switching segments. MRS Online Proceedings Library 1190, 0605 (2009). https://doi.org/10.1557/PROC-1190-NN06-05

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  • DOI: https://doi.org/10.1557/PROC-1190-NN06-05

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