Self-Assembled Lipid Tubules: Synthesis, Characterization, and Ordered Arrays

Abstract

The rolling of lipid bilayer sheets into hollow cylindrical tubules have emerged as a group of interesting supramolecular nanostructures. Here, we image the self-assembled tubules of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphochloline (DC8,9PC) with atomic force microscopy. Nanoscale ripple structures with a periodicity of ~ 200nm in the cylindrical lipid tubules are observed. We develop two simple methods based on microfluidic networks (µFN) and surface patterning to produce two dimensional ordered arrays of parallel aligned lipid tubules on substrates.

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Correspondence to Yue Zhao.

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Zhao, Y., Mahajan, N. & Fang, J. Self-Assembled Lipid Tubules: Synthesis, Characterization, and Ordered Arrays. MRS Online Proceedings Library 922, 502 (2006). https://doi.org/10.1557/PROC-0922-U05-02

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