Preparation and characteristics of novel poly-L-lactide/β-calcium metaphosphate fracture fixation composite rods

Abstract

A kind of novel poly-L-lactide (PLLA)/β-calcium metaphosphate (β-CMP) fracture-fixation composite rod was prepared by a two-step compression-molding method. The in vitro bioactivity of the composite rod was evaluated by investigating the effects of dissolved products from the composite rod on osteoblasts. In addition, the in vitro biocompatibility of the composite rod was evaluated by an osteoblast adhesion-and-proliferation assay. The products from composite rod dissolution significantly promoted cell growth. Furthermore, osteoblasts adhered and spread well on the rod. This PLLA/β-CMP composite rod has potential applications for clinical use following the assessment of adaptation during in vivo studies.

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Acknowledgments

Financial support by the Chinese National 863 Hi-tech Research Program (2002AA326080) and the Fund for Excellent Youth Teachers of the Education Ministry of China (2002123) are gratefully acknowledged. All of the tests in this article were performed by the Analytical and Testing Center of Sichuan University (Chengdu, People’s Republic of China).

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Correspondence to Guang-Fu Yin.

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Liao, L., Chen, L., Chen, AZ. et al. Preparation and characteristics of novel poly-L-lactide/β-calcium metaphosphate fracture fixation composite rods. Journal of Materials Research 22, 3324–3329 (2007). https://doi.org/10.1557/JMR.2007.0435

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