Abstract
The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine (Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, α-difluoromethylornithine (DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) (MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity.
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Unal, M., Palavan-Unsal, N. & Tufekci, M.A. Effects of Polyamines and Polyamine Biosynthetic Inhibitors on Mitotic Activity of Allium Cepa Root Tips. BIOLOGIA FUTURA 59, 93–102 (2008). https://doi.org/10.1556/ABiol.59.2008.1.8
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DOI: https://doi.org/10.1556/ABiol.59.2008.1.8