Abstract
Lectins are sugar-binding proteins and considered as attractive candidates for drug delivery and targeting. Here, we report the identifcation of the smallest lectin-like peptide (odorranalectin HYba) from the skin secretion of Hydrophylax bahuvistara which is being the shortest lectin-like peptide identifed so far from the frog skin secretion, with 15 amino acid residues. The peptide is the frst report from an Indian frog and lacks antimicrobial activity but strongly agglutinate intact human erythrocytes. The sequences at the L-fucose recognizing region is conserved as in other lectins reported from frog skin secretion and could be exploited for specifcity and drug targeting properties.
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References
Bies, C., Lehr, C. M., Woodley, J. F. (2004) Lectin-mediated drug targeting: history and applications. Drug Deliv. Rev. 56, 425–435.
Li, J., Wu, H., Hong, J., Xu, X., Yang, H. et al. (2008) Odorranalectin is a small peptide lectin with potential for drug delivery and targeting. PLoS ONE. 3, e2381.
Minko, T. (2004) Drug targeting to the colon with lectins and neoglycoconjugates. Adv. Drug Delivery Rev. 56, 491–509.
Sharon, N., Lis, H. (2004) History of lectins: from hemagglutinins to biological recognition molecules. Glycobiology 14, 53–62.
Thomas, P., Vineethkumar, T. V., Reshmy, V., Kumar, K. S., George, S. (2012) A mini review on the antimicrobial peptides isolated from the genus Hylarana (Amphibia: Anura) with a proposed nomenclature for amphibian skin peptides. Mol. Biol. Rep. 29, 6943–6947.
Vineethkumar, T. V., Shyla, G., George, S. (2016) First report of lividin and spinulosain peptides from the skin secretion of an Indian frog. Acta Biol. Hung. 67, 121–124.
Vineethkumar, T. V., Asha, R., Shyla, G., George, S. (2017) Identifcation and characterization of novel host defense peptides from the skin secretion of the fungoid frog, Hydrophylax bahuvistara (Anura: Ranidae). Chem. Biol. Drug Des. (in press).
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Vineethkumar, T.V., Shyla, G. & George, S. Smallest Lectin-Like Peptide Identified from the Skin Secretion of an Endemic Frog, Hydrophylax Bahuvistara. BIOLOGIA FUTURA 69, 110–113 (2018). https://doi.org/10.1556/018.68.2018.1.9
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DOI: https://doi.org/10.1556/018.68.2018.1.9