Abstract
Medial vestibular nucleus neurons show spontaneous repetitive spiking. This spiking activity was reproduced by a Hodgkin–Huxley-type mathematical model, which was developed in a previous study. The present study performed computer simulations of this model to evaluate the contribution of the excitatory ionic conductance to repetitive spiking. The present results revealed the difference in the influence of the transient sodium, persistent sodium, and calcium conductance on spiking activity. The differences between the present and previous results obtained from other neuronal mathematical models were discussed.
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References
Av-Ron, E., Vidal, P. P. (1999) Intrinsic membrane properties and dynamics of medial vestibular neurons: a simulation. Biol. Cyber. 80, 383–392.
Catterall, W. A., Raman, I. M., Robinson, H. P. C., Sejnowski, T. J., Paulsen, O. (2012) The Hodgkin- Huxley heritage: from channels to circuits. J. Neurosci. 32, 14064–14073.
Drion, G., Massotte, L., Sepulchre, R., Seutin, V. (2011) How modeling can reconcile apparently discrepant experimental results: The case of pacemaking in dopaminergic neurons. PLoS Comput. Biol. 7, e1002050.
Shirahata, T. (2011) The effect of variations in sodium conductance on pacemaking in a dopaminergic retinal neuron model. Acta Biol. Hung. 62, 211–214.
Shirahata, T. (2014) Effect of sodium conductance variations on electrical behavior of a neocortical neuron model. Acta Biol. Hung. 65, 379–384.
Shirahata, T. (2015) Numerical study of a mathematical model of vibrissa motoneurons: The relationship between repetitive spiking and two types of sodium conductance. Int. J. Theor. Math. Phys. 5, 48–52.
Shirahata, T. (2015) Numerical simulation analysis of a mathematical model of circadian pacemaker neurons. Appl. Math. 6, 1214–1219.
Szűcs, A. Huerta, R. (2015) Differential effects of static and dynamic inputs on neuronal excitability. J. Neurophysiol. 113, 232–243.
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Shirahata, T. Quantitative Evaluations of the Contribution of the Excitatory Ionic Conductance to Repetitive Spiking in a Mathematical Model of Medial Vestibular Nucleus Neurons. BIOLOGIA FUTURA 67, 215–219 (2016). https://doi.org/10.1556/018.67.2016.2.9
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DOI: https://doi.org/10.1556/018.67.2016.2.9