The Effects of Pituitary Adenylate Cyclase Activating Polypeptide in Renal Ischemia/Reperfusion

A Review

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide occurring in the nervous system as well as in the peripheral organs. Beneficial action of PACAP has been shown in different pathological processes. The strong protective effects of the peptide are probably due to its complex modulatory actions in antiapoptotic, anti-inflammatory and antioxidant pathways. In the kidney, PACAP is protective in models of diabetic nephropathy, myeloma kidney injury, cisplatin-, gentamycinand cyclosporin-induced damages. Numerous studies have been published describing the protective effect of this peptide in renal ischemia/reperfusion. The present review focuses on the ischemia/reperfusion-induced kidney injury and gives a brief summary about the results published in this area.

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Acknowledgements

Support by TAMOP 4.2.4.A/2-11-1-2012-0001 ‘National Excellence Program’, PTE-MTA Lendület Program, Arimura Foundation, OTKA K104984, OTKA PD 109644, Bolyai Scholarship, TÁMOP 4.2.2.A-11/1/KONV-2012-0024.

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Correspondence to Dóra Reglődi.

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László, E., Kiss, P., Horváth, G. et al. The Effects of Pituitary Adenylate Cyclase Activating Polypeptide in Renal Ischemia/Reperfusion. BIOLOGIA FUTURA 65, 369–378 (2014). https://doi.org/10.1556/ABiol.65.2014.4.1

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Keywords

  • Kidney
  • ischemia/reperfusion
  • PACAP
  • renoprotection