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Acta Biologica Hungarica

, Volume 63, Supplement 2, pp 210–216 | Cite as

Delayed Action of Serotonin in Molluscan Development

  • Elena E. Voronezhskaya
  • Marina Yu. Khabarova
  • L. P. Nezlin
  • E. G. IvashkinEmail author
Article
  • 1 Downloads

Abstract

Serotonin (5-HT) is known to induce a wide range of short-term and long-term (or delayed) effects. In the present paper we demonstrated that short time-window application of the 5-HT precursor 5-hydroxytryptophan during early cleavage stages results in both irreversible morphological malformation (exogastrulation) and distinct changes in behavior of young animals of the freshwater snail, Lymnaea stagnalis (Mollusca: Gastropoda). Pharmacological and immunocytochemical analysis confirmed that both the increase of intracellular 5-HT level within the cleaved blastomers and activation of membrane 5-HT2-like type receptors are required for the appearence of these phenomena.

Keywords

Serotonin precursor exogastrula young snail locomotion 

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© Akadémiai Kiadó, Budapest 2012

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Elena E. Voronezhskaya
    • 1
  • Marina Yu. Khabarova
    • 1
  • L. P. Nezlin
    • 1
  • E. G. Ivashkin
    • 1
    Email author
  1. 1.Department of Comparative PhysiologyInstitute of Developmental Biology RASMoscowRussia

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