Acta Biologica Hungarica

, Volume 63, Supplement 2, pp 210–216 | Cite as

Delayed Action of Serotonin in Molluscan Development

  • Elena E. Voronezhskaya
  • Marina Yu. Khabarova
  • L. P. Nezlin
  • E. G. IvashkinEmail author


Serotonin (5-HT) is known to induce a wide range of short-term and long-term (or delayed) effects. In the present paper we demonstrated that short time-window application of the 5-HT precursor 5-hydroxytryptophan during early cleavage stages results in both irreversible morphological malformation (exogastrulation) and distinct changes in behavior of young animals of the freshwater snail, Lymnaea stagnalis (Mollusca: Gastropoda). Pharmacological and immunocytochemical analysis confirmed that both the increase of intracellular 5-HT level within the cleaved blastomers and activation of membrane 5-HT2-like type receptors are required for the appearence of these phenomena.


Serotonin precursor exogastrula young snail locomotion 


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© Akadémiai Kiadó, Budapest 2012

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Elena E. Voronezhskaya
    • 1
  • Marina Yu. Khabarova
    • 1
  • L. P. Nezlin
    • 1
  • E. G. Ivashkin
    • 1
    Email author
  1. 1.Department of Comparative PhysiologyInstitute of Developmental Biology RASMoscowRussia

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