We examined GABAergic modulation on “slow” oscillation (<1.0 Hz) of the procerebrum in the terrestrial mollusk, Limax valentianus. Short application of GABA-receptor agonists slightly increased the frequency of a periodic oscillation in the procerebrum, whereas persistent application decreased it. GABA-receptor antagonists decreased the oscillatory frequency. The GABA-like immunoreactivities were found in the neuropil and the cell body layers of the procerebrum. Because GABAergic inhibition is known to be essential for the generation of “fast” synchronous neuronal oscillation in the CNSs in othre many animals, our present findings are first evidence suggesting that GABA modulates ‘slow’ oscillation in the CNS.
Cooke, I. R., Gelperin, A. (1988) Distribution of GABA-like immunoreactive neurons in the slug Limax maximus. Cell Tissue Res. 253, 77–81.
Kobayashi, S., Hattori, M., Ito, E. (2008) The effects of GABA on the network oscillations of the procerebrum in Limax valentianus. Acta Biol. Hung. 59, 77–79.
Lam, Y. W., Cohen, L. B., Wachowiak, M., Zochowski, M. R. (2000) Odors elicit three different oscillations in the turtle olfactory bulb. J. Neurosci. 20, 749–762.
MacLeod, K., Laurent, G. (1996) Distinct mechanisms for synchronization and temporal patterning of odor-encoding neural assemblies. Science 274, 976–979.
Matsuo, R., Kobayashi, S., Watanabe, S., Namiki, S., Iinuma, S., Sakamoto, H., Hirose, K., Ito, E. (2009) Glutamatergic neurotransmission in the procerebrum (olfactory center) of a terrestrial mollusk. J. Neurosci. Res. 87, 3011–3023.
Ratté, S., Chase, R. (1997) Morphology of interneurons in the procerebrum of the snail Helix aspersa. J. Comp. Neurol. 384, 359–372.
Watanabe, S., Kawahara, S., Kirino, Y. (1999) Glutamate induces Cl–and K+ currents in the olfactory interneurons of terrestrial slug. J. Comp. Physiol. A 184, 553–562.
Presented during the 12th ISIN Symposium on Invertebrate Neurobiology, August 31–September 4, 2011, Tihany, Hungary.
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Kobayashi, S., Ito, E. GABAergic Effects on the Slow Oscillatory Neural Activities in the Procerebrum of Limax valentianus. BIOLOGIA FUTURA 63, 91–95 (2012). https://doi.org/10.1556/ABiol.63.2012.Suppl.2.12
- oscillatory neural activity
- local field potential