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Acta Biologica Hungarica

, Volume 63, Supplement 2, pp 91–95 | Cite as

GABAergic Effects on the Slow Oscillatory Neural Activities in the Procerebrum of Limax valentianus

  • S. KobayashiEmail author
  • E. Ito
Short Communication

Abstract

We examined GABAergic modulation on “slow” oscillation (<1.0 Hz) of the procerebrum in the terrestrial mollusk, Limax valentianus. Short application of GABA-receptor agonists slightly increased the frequency of a periodic oscillation in the procerebrum, whereas persistent application decreased it. GABA-receptor antagonists decreased the oscillatory frequency. The GABA-like immunoreactivities were found in the neuropil and the cell body layers of the procerebrum. Because GABAergic inhibition is known to be essential for the generation of “fast” synchronous neuronal oscillation in the CNSs in othre many animals, our present findings are first evidence suggesting that GABA modulates ‘slow’ oscillation in the CNS.

Keywords

GABA oscillatory neural activity local field potential procerebrum Limax 

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Copyright information

© Akadémiai Kiadó, Budapest 2012

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.Kagawa School of Pharmaceutical SciencesTokushima Bunri UniversitySanuki, KagawaJapan

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