Acta Biologica Hungarica

, Volume 62, Issue 4, pp 426–440 | Cite as

Effects of a Porphyrazine Derivative on Some Developmental Characteristics of Drosophila Melanogaster

  • Ayla KaratasEmail author
  • Fatma Ertan
  • Neslihan Saki
  • Ensar Baspinar
  • A. M. Sevim
  • A. Gül


In this study, the effects of a porphyrazine derivative, [octakis (2-trimethylammoniumethyl thio) porphyrazinatocobalt] octaiodide (CoPzq), were explored on the developmental characteristics, sex ratio and egg fertility of Drosophila melanogaster. CoPzq was preferred in the study due to its probability to be used as a chemotherapeutic agent in medicine. As a result of the application of CoPzq, a phenotypic abnormality was revealed within the individuals of F1 and F2 generation of Drosophila. Although individuals of F2 generation did not directly come into contact with the chemical, the rate of abnormality is high. An increase was observed within both generations in terms of the egg fertility. Besides, a deviation emerged in the sex-ratio in some concentrations.


Porphyrazine Drosophila melanogaster toxic effect sex ratio egg fertility 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Alentorn, M. B., Xamena, N., Velazquez, A., Creus, A., Marcos, R. (1987) Studies on the toxicity of cypermethrin and fenvalerate in different strains of Drosophila melanogaster Meig. (Insecta, Diptera). Environ. Res. 43, 117–125.CrossRefGoogle Scholar
  2. 2.
    Bahçeci, D. (2000) The effects of malathion on Drosophila melanogaster’s development. M. S. Thesis, Gazi Univ. Grad. Sch. Nat. Appl. Sci. 5, 53–58. (In Turkish)Google Scholar
  3. 3.
    Barnes, A. I., Wigby, S., Bone, J. M., Partridge, L. (2008) Feeding, fecundity and life span in female Drosophila melanogaster. Proc. R. Soc. B. 275, 1675–1683.CrossRefGoogle Scholar
  4. 4.
    Bharucha, K. N. (2009) The epicurean fly: using Drosophila melanogaster to study metabolism. Pediatr Res. 65, 132–137.CrossRefGoogle Scholar
  5. 5.
    Cribbs, D. L., Pattatucci, A. M., Pultz, M. A., Kaufman, T. C. (1992) Ectopic expression of the Drosophila homeotic gene proboscipedia under Antennapedia P1 control causes dominant thoracic defects. Genetics 132, 699–711.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Goslinski, T., Osmalek, T., Mielcarek, J. (2009) Photochemical and spectral characterization of peripherally modified porphyrazines. Polyhedron 28, 3839–3843.CrossRefGoogle Scholar
  7. 7.
    Hepburn, D. D. D., Xiao, J., Bindom, S., Vincent, J. B., O’Donnell, J. (2003) Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster. Proc. Natl. Acad. Sci. 100, 3766–3771.CrossRefGoogle Scholar
  8. 8.
    Hoellinger, H., Lecorsier, A., Sonnier, M., Leger, C., Thang, D. C., Nam, N. H. (1987) Cytotoxicity, cytogenotoxicity and allergenicity tests on certain pyrethroids. Drug. Chem. Toxicol. 10, 291–310.CrossRefGoogle Scholar
  9. 9.
    Karataş, A., Bahçeci, Z. (2009) Effect of cypermethrin on some developmental stages of Drosophila melanogaster. Bull. Environ. Contam. Toxicol. 82, 738–742.CrossRefGoogle Scholar
  10. 10.
    Karataş, A., Bahçeci, Z. (2009) The effect of cypermethrin on adult individuals’ morphology and sex ratio on Drosophila melanogaster. Dumlupınar Univ. Grad. Sch. Nat. Appl. Sci. J. 19, 1–14. (In Turkish)Google Scholar
  11. 11.
    Karataş, A., Bahçeci, Z. (2009) Toxic effects of Diazinon on adult individuals of Drosophila melanogaster. J. Appl. Biological Sciences 3, 102–108.Google Scholar
  12. 12.
    Karataş, A., Bahçeci, Z. (2010) The effects of sodium arsenic and chromium(III) chloride on sex ratio and some developmental characteristics on Drosophila melanogaster. Erciyes Univ. Grad. Sch. Nat. Appl. Sci. J. 26, 102–111. (In Turkish)Google Scholar
  13. 13.
    Karataş A., Bahçeci, Z. (2010) The effects of sodium arsenic and chromium(III) chloride on adult individuals’ morphology on Drosophila melanogaster. Cumhuriyet Univ. Grad. Sch. Nat. Appl. Sci. J. 31, 1–21. (In Turkish)Google Scholar
  14. 14.
    Kavran, G., Akkus, H., Gul, A., Erim, F. B. (2002) Separation of positional isomers of aromatic anions by capillary electrophoresis using quaternized porphyrazine ion in aqueous solution. J. Sep. Sci. 25, 1–6.CrossRefGoogle Scholar
  15. 15.
    Kaya, B., Yanıkoğlu, A. (1999) The effects of 2,4-D and 4-CPA on living, development and adult individual ratio on F1, F2 and F3 generations of Drosophila melanogaster. Tr. J. Zool. 23, 297–301. (In Turkish)Google Scholar
  16. 16.
    Kryger, U., Deschodt, C., Davis, A. L., Scholtz, C. H. (2006) Effects of cattle treatment with a cypermethrin/cymiazol spray on survival and reproduction of the dung beetle species Euoniticellus intermedius (Coleoptera: Scarabaeidae). Bull. Entomol. Res. 96, 597–603.CrossRefGoogle Scholar
  17. 17.
    Lindsley, D. L., Zimm, G. G. (1992) The genome of Drosophila melanogaster. Academic Press, San Diego.Google Scholar
  18. 18.
    Liu, J., Qu, W., Kadiiska, M. B. (2009) Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol. Appl. Pharmacol. 238, 209–214.CrossRefGoogle Scholar
  19. 19.
    Manjunata, T., Hari Dass, S., Sharma, V. K. (2008) Egg-laying rhythm in Drosophila melanogaster. J. Genet. 87, 495–504.CrossRefGoogle Scholar
  20. 20.
    Mirabolghasemi, G., Mahnaz, A. (2002) Developmental changes in Drosophila melanogaster following exposure to alternating electromagnetic fields. Bioelectromagnetics 23, 416–420.CrossRefGoogle Scholar
  21. 21.
    Mukhopadhyay, I., Saxena, D. K., Chowdhuri, D. K. (2003) Hazardous effects of effluent from the chrome plating industry: 70 kda heat shock protein expression as a marker of cellular damage in transgenic Drosophila melanogaster (hsp70-lacZ). Environ. Health Perspectives 111, 1926–1932.CrossRefGoogle Scholar
  22. 22.
    Nazir, A., Mukhopadhyay, I., Saxena, D. K., Chowdhuri, D. (2001) Chlorpyrifos-induced hsp 70 expression and effect on reproductive performance in transgenic Drosophila melanogaster (hsp70- lacZ) bg9. Arch. Environ. Contam. Toxicol. 41, 443–449.CrossRefGoogle Scholar
  23. 23.
    Neuzil, E., Ballenger, J. (1952) Etude biologiaue de derives hydrosolubles des phthalocyanines. Compt. Rend. Soc. Biol. 146, 1108–1112.Google Scholar
  24. 24.
    Özkan, F. (1995) The effect of orally taked organophosphate insect malathion on Pimpla turionellae female individuals’ life span and egg fertility. M. S. Thesis, Çukurova Univ. Grad. Sch. Nat. Appl. Sci. 62–78. (In Turkish)Google Scholar
  25. 25.
    Partridge, L., Green, A., Fowler, K. (1987) Effects of egg-production and exposure to males on females survival in Drosophila melanogaster. J. Insect. Physiol. 33, 745–749.CrossRefGoogle Scholar
  26. 26.
    Polat, M., Gul, A. (2000) Synthesis of new porphyrazines with tertiary or quaternized aminoethyl substituents. Dyes Pigm. 45, 195–199.CrossRefGoogle Scholar
  27. 27.
    Reiter, L. T., Bier, E. (2002) Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. Expert. Opin. Ther. Targets. 6, 387–399.CrossRefGoogle Scholar
  28. 28.
    Salman, A. B., Marx, B. B., Harsman, L. G. (2001) A cost of reproduction in Drosophila melanogaster: stress susceptibility. Evolution 55, 1600–1608.CrossRefGoogle Scholar
  29. 29.
    Sandor, S., Prelipceanu, O., Checiu, I. (1985) Sulphonated phthalocyanine induced caudal malformative syndrome in the chick embryo. Teratology 32, 33–36.CrossRefGoogle Scholar
  30. 30.
    Shen, L. (2008) Theoretical investigation on the triplet excited state properties of the porphyrinrelated photosensitizers and the implications in illustrating their photosensitization mechanisms. J. Mol. Struct. 862, 130–132.CrossRefGoogle Scholar
  31. 31.
    Sholto, A., Lee, S., Hoffman, M. B., Barrett, A. G. M., Ehrenberg, B. (2008) Spectroscopy, binding to liposomes and production of singlet oxygen by porphyrazines with modularly variable water solubility. Photochem. Photobiol. 84, 764–773.CrossRefGoogle Scholar
  32. 32.
    Stallings, D. M., Hepburn, D. D. D., Hannah, M., Vincent, J. B., O’Donnel, J. (2006) Nutritional supplement chromium picolinate generates chromosomal aberrations and impedes progeny development in Drosophila melanogaster. Mutat. Res. 610, 101–113.CrossRefGoogle Scholar
  33. 33.
    Uysal, H., Kaya, Y. (2004) Toxicity of Euphorbia canariensis latex to some developmental stages of D. melanogaster (Drosophilidae). Bull. Environ. Contam. Toxicol. 72, 45–53.CrossRefGoogle Scholar
  34. 34.
    Vesper, B., Lee, S., Hammer, N. D., Elseth, K. M., Barrett, A. G. M., Hoffman, B. M., Radosevich, J. A. (2006) Developing a structure-function relationship for anionic porphyrazines exhibiting selective anti-tumor activity. J. Photochem. Photobiol. B 82, 180–186.CrossRefGoogle Scholar
  35. 35.
    Watson, J. D., Hopkins, N. H., Roberts, J. W., Steitz, J. A., Weiner, A. M. (1987) Mol. Biol. Gene 27, 110–114.Google Scholar
  36. 36.
    Wayne, M. L., Soundararajan, U., Harshman, L. G. (2006) Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg production. BMC Evolutionary Biology 6, 1–10.CrossRefGoogle Scholar
  37. 37.
    Weintraub, H., Abrovomici, A., Altman, A., Ben-Hur, E., Rosenthal, I. (1988) Laser Life Sci. 2, 185–190.Google Scholar
  38. 38.
    Wrenn, F. R., Good, M. L., Handler, P. (1951) Science 113, 525–530.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest 2011

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Ayla Karatas
    • 1
    Email author
  • Fatma Ertan
    • 2
  • Neslihan Saki
    • 2
  • Ensar Baspinar
    • 3
  • A. M. Sevim
    • 4
  • A. Gül
    • 4
  1. 1.Kocaeli University, Faculty of EducationKocaeliTurkey
  2. 2.Kocaeli University, Faculty of Arts and SciencesKocaeliTurkey
  3. 3.Sinop University, Faculty of Arts and SciencesSinopTurkey
  4. 4.Technical University of İstanbul, Faculty of Arts and SciencesİstanbulTurkey

Personalised recommendations