Acta Biologica Hungarica

, Volume 62, Issue 2, pp 211–214 | Cite as

The Effect of Variations in Sodium Conductances on Pacemaking in a Dopaminergic Retinal Neuron Model

  • T. ShirahataEmail author
Short Communication


Dopaminergic neurons in the retina show spontaneous tetrodotoxin-sensitive pacemaking, which has been explained by a reduced Hodgkin-Huxley-type computer model. The present study used this model to investigate the effect of variations in transient and persistent sodium conductance values on pacemaking, under variable leakage conductance levels. This study indicated that transient sodium conductance plays an indispensable role in pacemaking, which occurs under conditions in which only a persistent sodium conductance is considerably reduced, thus contributing to a detailed understanding of the relationship between sodium conductance and pacemaking.


Dopaminergic retinal neurons pacemaking model persistent sodium conductance transient sodium conductance 


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© Akadémiai Kiadó, Budapest 2011

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical SciencesTokushima Bunri UniversitySanuki, KagawaJapan

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