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Acta Biologica Hungarica

, Volume 62, Issue 1, pp 106–111 | Cite as

How Does it Act When Soluble? Critical Evaluation of Mechanism of Galectin-1 Induced T-Cell Apoptosis

  • Andrea Blaskó
  • Roberta Fajka-Boja
  • Gabriela Ion
  • Éva MonostoriEmail author
Open Access
Short Communication

Abstract

Galectin-1 (Gal-1), a mammalian lectin induces apoptosis of T lymphocytes. Contradictory data have resulted in confusing knowledge regarding mechanism of Gal-1 induced T-cell apoptosis. In this paper we aimed to resolve this controversy by comparing cell death induced by low (1.8 μM, lowGal-1) and high (18 μM, highGal-1) concentration of soluble Gal-1. We show that lowGal-1 and highGal-1 trigger phosphatidylserine exposure, generation of rafts and mitochondrial membrane depolarization. In contrast, lowGal-1 but not highGal-1 is dependent on the presence of p56lck and ZAP70 and activates caspase cascade. The results allow the conclusion that the cell-death mechanism strictly depends on the concentration of Gal-1.

Keywords

Galectin-1 apoptosis mechanism concentration dependence 

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Copyright information

© Akadémiai Kiadó, Budapest 2011

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Andrea Blaskó
    • 1
  • Roberta Fajka-Boja
    • 1
  • Gabriela Ion
    • 1
  • Éva Monostori
    • 1
    Email author
  1. 1.Biological Research CenterHungarian Academy of SciencesSzegedHungary

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