Altered Open Field Behavior in Rats Induced by Acute Administration of 3-Nitropropionic Acid: Possible Glutamatergic and Dopaminergic Involvement

Abstract

3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.

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Correspondence to A. Papp.

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Lukács, A., Szabó, A., Papp, A. et al. Altered Open Field Behavior in Rats Induced by Acute Administration of 3-Nitropropionic Acid: Possible Glutamatergic and Dopaminergic Involvement. BIOLOGIA FUTURA 60, 359–367 (2009). https://doi.org/10.1556/ABiol.60.2009.4.3

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Keywords

  • 3-nitropropionic acid
  • locomotor activity
  • open field
  • rat