Altered Open Field Behavior in Rats Induced by Acute Administration of 3-Nitropropionic Acid: Possible Glutamatergic and Dopaminergic Involvement
3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.
Keywords3-nitropropionic acid locomotor activity open field rat
Unable to display preview. Download preview PDF.
- 4.Beal, M. F., Brouillet, E., Jenkins, B. G., Ferrante, R. J., Kowall, N. W., Miller, J. M., Storey, E., Srivastava, R., Rosen, B. R., Hyman, B. T. (1993) Neurochemical and histological characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitroproprionic acid. J. Neurosci. 13, 4181–4192.CrossRefGoogle Scholar
- 10.Hersch, S. M., Ciliax, B. J., Gutekunst, C-A., Rees, H. D., Heilman, C. J., Yung, K. K. L., Bolam, J. P., Ince, E., Yi, H., Levey, A. I. (1995) Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. J. Neurosci. 15, 5222–5237.CrossRefGoogle Scholar
- 17.Lukács, A., Szabó, A., Nagymajtényi, L. (2005) Changes in neurobehavioural parameters and spontaneous cortical activity in rats after acute single and combined exposure by 3-nitropropionic acid and MK-801. Homeostasis 43, 169–172.Google Scholar
- 18.Lukács, A., Szabó, A., Vezér, T., Papp, A. (2006) The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats. Acta Neurobiol. Exp. 66, 227–233.Google Scholar
- 19.Lukács, A., Szabó, A., Vezér, T., Papp, A. (2007) Immediate and acute neurobehavioural effects of a glutamate agonist and antagonist in rats. Clin. Neurosci. 60, 42.Google Scholar
- 21.Nishino, H., Kumazaki, M., Fukuda, A., Fujimoto, I., Shimano, Y., Hida, H., Sakurai, T., Deshpande, S. B., Shimizu, H., Morikawa, S., Inubushi, T. (1997) Acute 3-nitropropionic acid intoxication induces striatal astrocytic cell death and dysfunction of the blood-brain barrier: involvement of dopamine toxicity. Neurosci. Res. 27, 343–355.CrossRefGoogle Scholar
- 28.Szabó, A., Papp, A. (2003) Instantaneous and subacute functional neurotoxic effects elicited in rats by 3-nitropropionic acid. Clin. Neurosci. 56, 84.Google Scholar
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.