Acta Biologica Hungarica

, Volume 60, Issue 4, pp 359–367 | Cite as

Altered Open Field Behavior in Rats Induced by Acute Administration of 3-Nitropropionic Acid: Possible Glutamatergic and Dopaminergic Involvement

  • Anita Lukács
  • Andrea Szabó
  • A. PappEmail author
  • Tünde Vezér


3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.


3-nitropropionic acid locomotor activity open field rat 


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© Akadémiai Kiadó, Budapest 2009

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Anita Lukács
    • 1
  • Andrea Szabó
    • 1
  • A. Papp
    • 1
    Email author
  • Tünde Vezér
    • 1
  1. 1.Department of Public HealthUniversity of SzegedSzegedHungary

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