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Acta Biologica Hungarica

, Volume 60, Issue 4, pp 359–367 | Cite as

Altered Open Field Behavior in Rats Induced by Acute Administration of 3-Nitropropionic Acid: Possible Glutamatergic and Dopaminergic Involvement

  • Anita Lukács
  • Andrea Szabó
  • A. PappEmail author
  • Tünde Vezér
Article

Abstract

3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats in a single 20 mg/kg b.w. dose, and the resulting behavioral alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioral effect of 3-NP.

Keywords

3-nitropropionic acid locomotor activity open field rat 

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© Akadémiai Kiadó, Budapest 2009

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Anita Lukács
    • 1
  • Andrea Szabó
    • 1
  • A. Papp
    • 1
    Email author
  • Tünde Vezér
    • 1
  1. 1.Department of Public HealthUniversity of SzegedSzegedHungary

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