Acta Biologica Hungarica

, Volume 60, Issue 1, pp 79–88 | Cite as

Changes in Antioxidant Status and Biochemical Parameters after Orally Cadmium Administration in Females Rats

  • S. ChaterEmail author
  • T. Douki
  • A. Favier
  • M. Sakly
  • H. Abdelmelek
Open Access


The research was conducted to investigate the toxic effects of cadmium chloride (CdCl2), administered during gestation period on female Wistar rats. Pregnant rats received CdCl2 (20 mg/1, orally) from Day 6 to Day 19 of pregnancy. Results showed that Cd treatment induced a decrease in body weight gain. The relative liver weight increased significantly, with a marked decrease of glycogen and total lipids content. The administration of Cd induced hepatotoxicity as indicated by elevations in plasma alanine aminotransferase (ALT), aspartate aminotransferase and lactate dehydrogenase (LDH) activities (p < 0.05). Treatment with CdCl2 caused a significant (p < 0.05) increase in glucose. A significant increase was observed in the level of MDA and 8-oxodGuo tissues in the cadmium-exposed group compared to the control group (p < 0.05). Results showed that cadmium given to dams led to an oxidative stress and DNA damage in tissues of pregnant rats.


Cadmium malondialdehyde 8-oxodGuo pregnancy 



This work was supported the Tunisian Ministry of Higher Education. The authors gratefully acknowledge the technical assistance of Mr Bechir Azib.


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© Akadémiai Kiadó, Budapest 2009

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Authors and Affiliations

  • S. Chater
    • 1
    • 2
    • 3
    Email author
  • T. Douki
    • 2
  • A. Favier
    • 2
    • 3
  • M. Sakly
    • 1
  • H. Abdelmelek
    • 1
  1. 1.Laboratoire de Physiologie IntégréeFaculté des Sciences de BizerteJarzounaTunisia
  2. 2.DRFMC/SCIBLaboratoire Lésions des Acides Nucléiques CEA/GrenobleGrenoble cedex 9France
  3. 3.Département de Biologie Intégrée, Laboratoire du Stress OxydantHôpital la TrancheGrenobleFrance

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