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Acta Biologica Hungarica

, Volume 59, Supplement 2, pp 237–239 | Cite as

Neuropeptides and Their Receptors of the Protochordate, Ciona intestinalis: The Evolutionary Origin of Vertebrate Neuropeptides

Short Communication
  • H. SatakeEmail author
  • M. Aoyama
  • T. Kawada
  • T. Sekiguchi
  • T. Sakai
  • M. Fujie
  • Nori Satoh
Article

Abstract

Ci-TK and Ci-TK-R are authentic tachykinin (TK) and TK receptor isolated from a protochordate, Ciona intestinalis. In this study, we investigated a novel function of TK as an enhancer of oocyte growth. Ci- TK-R is expressed specifically in the Ciona vitellogenic oocytes. Moreover, administration of Ci-TK to the Ciona ovary resulted in upregulation of gene expression and enzymatic activity of several proteases. Moreover, maturation of the Ciona oocytes from the vitellogenic stage to the post-vitellogenic stage was induced in the presence of Ci-TK, which was completely blocked by addition of protease inhibitors.

Keywords

Tachykinin ascidian Ciona intestinalis neuropeptide oocyte 

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References

  1. 1.
    Satake, H., Kawada T. (2006) Neuropeptides, hormones, and their receptors in ascidians-emerging model animals. In: Satake, H. (ed.) Invertebrate Neuropeptides and Hormones: Basic Knowledge and Recent Advances. Transworld Research Network, Kerala, India, pp. 253–276.Google Scholar
  2. 2.
    Satake, H., Ogasawara, M., Kawada, T., Masuda, K., Aoyama, M., Minakata, H., Chiba, T., Metoki, H., Satou, Y., Satoh, N. (2004) Tachykinin and tachykinin receptor of an ascidian, Ciona intestinalis: evolutionary origin of the vertebrate tachykinin family. J. Biol. Chem.. 279, 53798–53805.CrossRefGoogle Scholar
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    Satake, H., Kawada, T. (2006) Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors. Curr. Drug Targets. 7, 963–974.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest 2008

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • H. Satake
    • 1
    Email author
  • M. Aoyama
    • 1
  • T. Kawada
    • 1
  • T. Sekiguchi
    • 1
  • T. Sakai
    • 1
  • M. Fujie
    • 2
  • Nori Satoh
    • 3
  1. 1.Suntory Institute for Bioorganic ResearchOsakaJapan
  2. 2.CREST, JSTTokyoJapan
  3. 3.Department of Zoology, Graduate School of ScienceKyoto UniversityKyotoJapan

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