Neuropeptides and Their Receptors of the Protochordate, Ciona intestinalis: The Evolutionary Origin of Vertebrate Neuropeptides

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Abstract

Ci-TK and Ci-TK-R are authentic tachykinin (TK) and TK receptor isolated from a protochordate, Ciona intestinalis. In this study, we investigated a novel function of TK as an enhancer of oocyte growth. Ci- TK-R is expressed specifically in the Ciona vitellogenic oocytes. Moreover, administration of Ci-TK to the Ciona ovary resulted in upregulation of gene expression and enzymatic activity of several proteases. Moreover, maturation of the Ciona oocytes from the vitellogenic stage to the post-vitellogenic stage was induced in the presence of Ci-TK, which was completely blocked by addition of protease inhibitors.

References

  1. 1.

    Satake, H., Kawada T. (2006) Neuropeptides, hormones, and their receptors in ascidians-emerging model animals. In: Satake, H. (ed.) Invertebrate Neuropeptides and Hormones: Basic Knowledge and Recent Advances. Transworld Research Network, Kerala, India, pp. 253–276.

    Google Scholar 

  2. 2.

    Satake, H., Ogasawara, M., Kawada, T., Masuda, K., Aoyama, M., Minakata, H., Chiba, T., Metoki, H., Satou, Y., Satoh, N. (2004) Tachykinin and tachykinin receptor of an ascidian, Ciona intestinalis: evolutionary origin of the vertebrate tachykinin family. J. Biol. Chem.. 279, 53798–53805.

    CAS  Article  Google Scholar 

  3. 3.

    Satake, H., Kawada, T. (2006) Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors. Curr. Drug Targets. 7, 963–974.

    CAS  Article  Google Scholar 

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Correspondence to H. Satake.

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Satake, H., Aoyama, M., Kawada, T. et al. Neuropeptides and Their Receptors of the Protochordate, Ciona intestinalis: The Evolutionary Origin of Vertebrate Neuropeptides. BIOLOGIA FUTURA 59, 237–239 (2008). https://doi.org/10.1556/ABiol.59.2008.Suppl.33

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Keywords

  • Tachykinin
  • ascidian
  • Ciona intestinalis
  • neuropeptide
  • oocyte