How Messengers Modulate the Shifting of Spontaneously Generated Action Potential Into Bursts of Potentials in Central Snail Neuron?

Abstract

How messengers modulate the shifting of spontaneously generated action potential into bursts of potentials (BoP) is studied electrophysiologically and biochemically in RP 1 and 4 neurons of the African snail, Achatina fulica Ferussac using d- and l-amphetamine (Amp) as modulator. The stereospecific effects, extracellular and intracellular ionic effects, messenger related to enzymatic effects and membrane ionic currents effects on BoP elicited by Amp are studied. The roles of organelles, such as mitochondria, protein syntheis related endoplasmic-reticulum, on the BoP are also tested. The messengers modulated the BoP are discussed.

References

  1. 1.

    Adams, D. J., Smith, S. J., Thompson, S. H. (1980) Ionic currents in molluscan soma. Annu. Rev. Neurosci. 3, 141–167.

    CAS  Article  Google Scholar 

  2. 2.

    Arvanov, V. L., Chen, R. C., Chen, Y. H., Chang, Y. C., Liou, H. H., Arvanov, V. A., Tsai, M. C. (1994) Modulation of pentylenetetrazol induced bursting activity by elelctrogenic Na pump. Asia: Pacific. J. Pharmacol. 9, 37–42.

    CAS  Google Scholar 

  3. 3.

    Cooper, D. C. (2002) The significance of action potential bursting in the brain reward circuit. Neurochem. Int. 41, 333–340.

    CAS  Article  Google Scholar 

  4. 4.

    Duchen, M. R. (2000) Mitochondria and calcium: from cell signalling to cell death. J. Physiol. 529 (Pt 1), 57–68.

    CAS  Article  Google Scholar 

  5. 5.

    Lee, I. N., Chen, C. H., Sheu, J. C., Lee, H. S., Huang, G. T., Chen, D. S., Yu, C. Y., Wen, C. L., Lu, F. J., Chow, L. P. (2006) Identification of complement C3a as a candidate biomarker in human chronic hepatitis C and HCV-related hepatocellular carcinoma using a proteomics approach. Proteomic. 6, 2865–2873.

    CAS  Article  Google Scholar 

  6. 6.

    Lee, I. N., Chen, C. H., Sheu, J. C., Lee, H. S., Huang, G. T., Yu, C. Y., Lu, F. J., Chow, L. P. (2005) Identification of human hepatocellular carcinoma-related biomarkers by two-dimensional difference gel electrophoresis and mass spectrometry. Proteome Res. 4, 2062–2069.

    CAS  Article  Google Scholar 

  7. 7.

    Lin, C. H., Tsai, M. C. (2005) The modulation effects of d-amphetamine and procaine on the spontaneously generated action potentials in the central neuron of snail, Achatina fulica Ferussac. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 141, 58–68.

    Google Scholar 

  8. 8.

    Lin, C. H., Tsai, M. C. (2003) D-amphetamine-elicited action potential bursts in central snail neurons: role of second messenger systems. J. Formos. Med. Assoc. 102, 394–403.

    CAS  PubMed  Google Scholar 

  9. 9.

    Lin, C. H., Wu, C. L., Lin, M. S., Liu, M. C., Lin, P. J., Tsai, M. C. (2005) Effects of 2,3-butanedione monoxime on induction of action potential bursts in central snail neurons: direct and indirect modulations of ionic currents. Pharmacolog. 73, 57–69.

    CAS  Google Scholar 

  10. 10.

    Lin, C. K., Lin, P. J., Chen, I. M., Chen, I. H., Lin, P. L., Zhuravlev, V. L., Tsai, M. C. (2006) Seizure discharges induced by amphetamine in neuron of african snail Achatina fulica: effects of phosphodiesterase inhibitors. Zh: Evol. Biokhim. Fiziol. 42, 134–139.

    Google Scholar 

  11. 11.

    Macdonald, R. L., Kelly, K. M. (1995) Antiepileptic drug mechanisms of action. Epilepsia: 36 (Suppl. 2), S2–12.

    Article  Google Scholar 

  12. 12.

    McCormick, D. A., Contreras, D. (2001) On the cellular and network bases of epileptic seizures. Annu. Rev. Physiol. 63, 815–846.

    CAS  Article  Google Scholar 

  13. 13.

    Milligan, J. F., Groebe, D. R., Witherell, G. W., Uhlenbeck, O. C. (1987) Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucl. Acids Res. 15, 8783–8798.

    CAS  Article  Google Scholar 

  14. 14.

    Susswein, A. J., Hurwitz, I., Thorne, R., Byrne, J. H., Baxter, D. A. (2002) Mechanisms underlying fictive feeding in aplysia: coupling between a large neuron with plateau potentials activity and a spiking neuron. J. Neurophysiol. 87, 2307–2323.

    Article  Google Scholar 

  15. 15.

    Tsai, M. C., Chen, Y. H. (1995) Bursting firing of action potential in central snail neuron elicited by d-amphetamine: role of electrogenic sodium pump. Comp. Biochem. Physiol. 111c, 131–141.

    CAS  Google Scholar 

  16. 16.

    Tsai, M. C., Chen, Y. H., Huang, S. S. (2000) Amphetamine elicited potential changes in vertebrate and invertebrate central neurons. Acta Biol. Hung. 51, 275–286.

    CAS  PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to M. C. Tsai.

Rights and permissions

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Reprints and Permissions

About this article

Cite this article

Tsai, M.C. How Messengers Modulate the Shifting of Spontaneously Generated Action Potential Into Bursts of Potentials in Central Snail Neuron?. BIOLOGIA FUTURA 59, 13–22 (2008). https://doi.org/10.1556/ABiol.59.2008.Suppl.2

Download citation

Keywords

  • Amphetamine
  • bursts of potentials
  • messengers
  • ionic current
  • cAMP
  • protein synthesis inhibitor
  • calcium image
  • modulation