Acta Biologica Hungarica

, Volume 58, Issue 4, pp 441–443 | Cite as

The Effect of Chronic Diazepam Administration on Lipid Peroxidation and Ca2+-Atpase Activity in Rat Liver

Short Communication
  • Şule SeçkinEmail author
  • Şeyda Alsancak
  • Canan Başaran-Küçükgergin
  • Müjdat Uysal


Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH) content. DZP also markedly lowered Ca2+ATPase activity. Treatment with Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased lipid peroxidation together with alteration in Ca2+-ATPase activity may play a role in DZP induced hepatic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxi-city.


Diazepam lipid peroxidation Ca2+-ATPase rat liver 


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© Akadémiai Kiadó, Budapest 2007

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Şule Seçkin
    • 1
    Email author
  • Şeyda Alsancak
    • 1
  • Canan Başaran-Küçükgergin
    • 1
  • Müjdat Uysal
    • 1
  1. 1.Department of Biochemistry, Istanbul Faculty of MedicineIstanbul University, ÇapaIstanbulTurkey

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