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Acta Biologica Hungarica

, Volume 58, Issue 4, pp 441–443 | Cite as

The Effect of Chronic Diazepam Administration on Lipid Peroxidation and Ca2+-Atpase Activity in Rat Liver

Short Communication
  • Şule SeçkinEmail author
  • Şeyda Alsancak
  • Canan Başaran-Küçükgergin
  • Müjdat Uysal
Article

Abstract

Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH) content. DZP also markedly lowered Ca2+ATPase activity. Treatment with Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased lipid peroxidation together with alteration in Ca2+-ATPase activity may play a role in DZP induced hepatic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxi-city.

Keywords

Diazepam lipid peroxidation Ca2+-ATPase rat liver 

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© Akadémiai Kiadó, Budapest 2007

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Şule Seçkin
    • 1
    Email author
  • Şeyda Alsancak
    • 1
  • Canan Başaran-Küçükgergin
    • 1
  • Müjdat Uysal
    • 1
  1. 1.Department of Biochemistry, Istanbul Faculty of MedicineIstanbul University, ÇapaIstanbulTurkey

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