The Effect of Chronic Diazepam Administration on Lipid Peroxidation and Ca2+-Atpase Activity in Rat Liver
Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH) content. DZP also markedly lowered Ca2+ATPase activity. Treatment with Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased lipid peroxidation together with alteration in Ca2+-ATPase activity may play a role in DZP induced hepatic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxi-city.
KeywordsDiazepam lipid peroxidation Ca2+-ATPase rat liver
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