The Effect of Chronic Diazepam Administration on Lipid Peroxidation and Ca2+-Atpase Activity in Rat Liver

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Abstract

Chronic administration of diazepam (DZP) caused an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH) content. DZP also markedly lowered Ca2+ATPase activity. Treatment with Se plus vitamin E reduced MDA levels and increased GSH content. Our results suggest that, increased lipid peroxidation together with alteration in Ca2+-ATPase activity may play a role in DZP induced hepatic injury and Se plus vitamin E treatment may contribute to the attenuation of DZP induced hepatotoxi-city.

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Correspondence to Şule Seçkin.

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Seçkin, Ş., Alsancak, Ş., Başaran-Küçükgergin, C. et al. The Effect of Chronic Diazepam Administration on Lipid Peroxidation and Ca2+-Atpase Activity in Rat Liver. BIOLOGIA FUTURA 58, 441–443 (2007). https://doi.org/10.1556/ABiol.58.2007.4.11

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Keywords

  • Diazepam
  • lipid peroxidation
  • Ca2+-ATPase
  • rat liver