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Acta Biologica Hungarica

, Volume 57, Issue 4, pp 433–439 | Cite as

Immunotoxicological Investigation of Subacute Combined Exposure with Low Doses of Pb, Hg and Cd in Rats

  • L. InstitórisEmail author
  • Dóra Kovács
  • I. Kecskeméti-Kovács
  • Anita Lukács
  • Andrea Szabó
  • Zsuzsanna Lengyel
  • A. Papp
  • L. Nagymajtényi
  • I. Dési
Article

Abstract

Detectable interactions between NOEL (No Observed Effect Level) doses of Pb, Hg and Cd in general toxicological, hematological, and immune function parameters were investigated. The metals (Pb-acetate, 20 mg/kg; HgCl2, 0.40 mg/kg; CdCl2, 1.61 mg/kg) were combined. First, the rats received the combination Pb + Hg + Cd for 4 weeks per os. Significant difference vs. control was found only in the weight of lung and popliteal lymph node (PLN). The Pb + Hg and Pb + Cd combinations significantly decreased the PLN to 100 g body weight and PLN to brain weight ratio, and Pb+Hg also decreased the relative adrenal weight. After 12 weeks treatment with the same doses, effects on the thymus, kidney, and adrenal weights in the Pb + Hg, and thymus weight in the Pb + Cd, combination were seen. Pb + Cd also affected the white and red blood cell count and hematocrit. Combined with Hg or Cd, NOEL dose Pb showed toxicity, indicating that exposure limits may be inefficient in combined exposure situations.

Keywords

Immunotoxicity hematology heavy metals combination rat 

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Copyright information

© Akadémiai Kiadó, Budapest 2006

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • L. Institóris
    • 1
    Email author
  • Dóra Kovács
    • 1
  • I. Kecskeméti-Kovács
    • 1
  • Anita Lukács
    • 1
  • Andrea Szabó
    • 1
  • Zsuzsanna Lengyel
    • 1
  • A. Papp
    • 1
  • L. Nagymajtényi
    • 1
  • I. Dési
    • 1
  1. 1.Department of Public Health, Faculty of MedicineUniversity of SzegedSzegedHungary

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