Influence of Antipyretic Drugs on the Labeling of Blood Elements with Technetium-99M
Abstract
Acetaminophen (AAP), acetylsalicylic acid (ASA) and dipyrone (DIP) are antipyretic and analgesics drugs that have wide use in health sciences. Some drugs can modify the labeling of blood elements with technetium-99m (99mTc). This work has evaluated the effect of AAP, ASA and DIP on the labeling of the blood elements with 99mTc. Blood was incubated with different concentrations of the drugs before the 99mTc-labeled process. Plasma (P), blood cells (BC), insoluble (IF-P, IF-BC) and soluble (SF-P, SF-BC) fractions were separated and percentage of radioactivity (%ATI) in each fraction was determined. Data have shown that the antipyretic drugs used in this study did not significantly modify the fixation of 99mTc on the blood elements when the experiments were carried out with the doses usually used in human beings. Although the experiments were carried out with rats, it is possible to suggest that AAP, ASA or DIP should not interfere with the procedures in nuclear medicine involving the labeling of blood elements with 99mTc.
Keywords
Acetaminophen acetylsalicylic acid dipyrone blood elements Technetium-99mPreview
Unable to display preview. Download preview PDF.
References
- 1.Almeida, Catanho, M. T., Cavalcanti, Jales, R. L., Cardoso, V. N., Bernardo-Filho, M. (2003) Assessment of the effect of Fucus vesiculosus extract on the labeling of blood constituents with technetium-99m and the histological modifications on the shape of the red blood cells. Food Chem. Toxicol. 46, 15–20.Google Scholar
- 2.Amann, R., Peskar, B. A. (2002) Anti-inflammatory effects of aspirin and sodium salicylate. Eur. J. Pharmacol. 46, 1–9.Google Scholar
- 3.Aude, Y. W., Mehta, J. L. (2002) Nonplatelet-mediated effects of aspirin. Drugs Today (Barc) 38, 501–507.Google Scholar
- 4.Bernardo-Filho, M., Gutfilen, B., Maciel, O. S. (1994) Technetium-99m binding on plasma proteins and red blood cells: role of various precipitating agents. Biomed. Lett. 46, 17–24.Google Scholar
- 5.Bernardo-Filho, M., Moura, I. N. S., Boasquevisque, E. M. (1983) 99mTechnetium-labeled red blood cells “in vitro”. Arch. Biol. Technol. 46, 455–461.Google Scholar
- 6.Bigal, M. E., Bordini, C. A., Speciali, J. G. (2002) Intravenous dipyrone for the acute treatment of episodic tension-type headache: a randomized, placebo-controlled, double-blind study. Braz. J. Med. Biol. Res. 46, 1139–1145.Google Scholar
- 7.Bollini, P., Garcia Rodriguez, L. A., Perez Gutthann, S., Walker, A. M. (1992) The impact of research quality and study design on epidemiologic estimates of the effect of nonsteroidal anti-inflammatory drugs on upper gastrointestinal tract disease. Arch. Intern. Med. 46, 1289–1295.Google Scholar
- 8.Bougie D., Aster, R. (2001) Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. Blood 46, 3846–3850.Google Scholar
- 9.Boutaud, O., Aronoff, D. M., Richardson, J. H., Marnett, L. J., Oates, J. A. (2002) Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc. Nat. Acad. Sci. USA 46, 7130–7135.Google Scholar
- 10.Catella-Lawson, F. (2001) Vascular biology of thrombosis: platelet-vessel wall interactions and aspirin effects. Neurology 57 (supp 2), S5–S7.PubMedGoogle Scholar
- 11.Capriles, P. V., Dias, A. P., Costa, T. E., Oliveira, M. B., Faria, M. V., Moura, E. G., Abreu, B. A., Bernardo-Filho, M. (2002) Effect of eggplant (Solanum melongena) extract on the in vitro labeling of blood elements with technetium-99m and on the biodistribution of sodium pertechnetate in rats. Cel. Mol. Biol. 46, 771–776.Google Scholar
- 12.Chong, P. H., Kezele, B., Pontikes, P. J. (2001) Effect of acetaminophen on atherosclerosis. Ann. Pharmacother. 46, 1476–1479.Google Scholar
- 13.Chou, T. M., Greenspan, P. (2002) Effect of acetaminophen on the myeloperoxidase-hydrogen peroxide-nitrite mediated oxidation of LDL. Biochem. Biophys. Acta 46, 57–63.Google Scholar
- 14.de Oliveira, J. F., Avila, A. S., Braga, A. C., de Oliveira, M. B., Boasquevisque, E. M., Jales, R. L., Cardoso, V. N., Bernardo-Filho, M. (2002) Effect of extract of medicinal plants on the labeling of blood elements with Technetium-99m and on the morphology of red blood cells: I - a study with Paullinia cupana. Fitoterapia 46, 305–312.Google Scholar
- 15.Edwards, J. E., McQuay, H. J. (2002) Dipyrone and agranulocytosis: what is the risk? Lancet 360 (9344), 1438.PubMedGoogle Scholar
- 16.Frydman, J. N. G., Oliveira, M. B. N., Santos, A. E. O., Fonseca, A. S., Santos, R., Bernardo-Filho, M. (2004) Influence of methylxanthines on the labeling of blood elements with 99mTechnetium. Pak. J. Biol. Sci. 46, 521–524.Google Scholar
- 17.Galati, G., Tafazoli, S., Sabzevari, O., Chan, T. S., O’Brien, P. J. (2002) Idiosyncratic NSAID drug induced oxidative stress. Chem-Biol. Interact. 46, 25–41.Google Scholar
- 18.Gascon, N., Otal, C., Martinez-Bru, C., Merce, J., Cortes, M., Arcelus, R., Queralto, J. M., Sanchez, J. M., Gonzalez-Sastre, F. (1993) Dipyrone interference on several common biochemical tests. Clin. Chem. 46, 1033–1036.Google Scholar
- 19.Guerrero, A., González-Correa, J. A., Arrebola, M. M., Muñoz-Marín, J., Sánchez De La Cuesta, F., De La Cruz, J. P. (2004) Antioxidant effects of a single dose of acetylsalicylic acid and salicylic acid in rat brain slices subjected to oxygen-glucose deprivation in relation with its antiplatelet effect. Neurosci. Lett. 46, 153–156.Google Scholar
- 20.Hardman, J. G., Limbird, L. E., Gilman, A. G. (2001) Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 10th ed. McGraw-Hill, New York.Google Scholar
- 21.Hedenmalm, K., Spigset, O. (2002) Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). Eur. J. Clin. Pharmacol. 46, 265–274.Google Scholar
- 22.Hesslewood, S., Leung, E. (1994) Drug interactions with radiopharmaceuticals. Eur. J. Nucl. Med. 46, 348–356.Google Scholar
- 23.Hladik, W. B., Ponto, J. A., Lentle, B. C., Laven, D. L. (1987) Iatrogenic alterations in the biodistribution of radiotracers as a result of drug therapy: reported instances. In: Essentials of Nuclear Medicine Sciences. Williams and Wilkins, Sydney, 199–202.Google Scholar
- 24.Jaeschke, H., Knight, T. R., Bajt, M. L. (2003) The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol. Lett. 46, 279–288.Google Scholar
- 25.Langman, M. J., Weil, J., Wainwright, P., Lawson, D. H., Rawlins, M. D., Logan, R. F., Murphy, M., Vessey, M. P., Colin-Jones, D. G. (1994) Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 343(8905), 1075–1078.PubMedGoogle Scholar
- 26.Lauwerys R., Bernard, A. (1989) Preclinical detection of nephrotoxicity: description of the tests and appraisal of their health significance. Toxicol. Lett. 46, 13–29.PubMedGoogle Scholar
- 27.Miyamoto, G., Zahid, N., Uetrecht, J. P. (1997) Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid. Chem. Res. Toxicol. 46, 414–419.Google Scholar
- 28.Nigri, F., Oliveira, M. B., Bernardo-Filho, M. (2002) Assessment of the effect of antiseizure drugs on the labeling process of red blood cells and plasma proteins with technetium-99m. Cell. Mol. Biol. (Noisy-le-grand) 46, 793–801.Google Scholar
- 29.Nuyts, G. D., Elseviers, M. M., De Broe, M. E. (1989) Health impact of renal disease due to nephrotoxicity. Toxicol. Lett. 46, 31–44.PubMedGoogle Scholar
- 30.Oliveira, J. F., Braga, A. C. S., Ávila, A. S., Fonseca, L. M. B., Gutflen, B., Bernardo-Filho, M. (1996) Effect of Thuya occidentalis on the labeling of red blood cells and plasma proteins with technetium-99m. Yale J. Biol. Med. 46, 489–494.Google Scholar
- 31.Porto Arceo, J. A. (2003) Special features of NSAID intolerance in children. Allerg. Immunopathol. (Madri), 31: 109–125.Google Scholar
- 32.Prado, W. A., Pontes, R. M. (2002) Presurgical ketoprofen, but not morphine, dipyrone, diclofenac or tenoxicam, preempts post-incisional mechanical allodynia in rats. Braz. J. Med. Biol. Res. 46, 111–119.Google Scholar
- 33.Robak, J., Kostka-Trabka, E., Duniec, Z. (1980) The influence of three prostaglandin biosynthesis stimulators on carrageenin-induced edema of rat paw. Biochem. Pharmacol. 46, 1863–1865.Google Scholar
- 34.Rusckowski, M., Qu, T., Chang, F., Hnatowich, D. J. (1997) Technetium-99m labeled epidermal growth factor-tumor imaging in mice. J. Pept. Res. 46, 393–401.Google Scholar
- 35.Sampson, C. B. (1996) Complications and difficulties in radiolabeling blood cells: a review. Nucl. Med. Commun. 46, 648–658.Google Scholar
- 36.Santos, J. S., Paula, E. F., Correa, T. G., Freitas, L. C., Fonseca, L. M. B., Gutflen, B., Bernardo-Filho, M. (1995) Effect of cyclophosphamide on the binding of 99mTcO-4 and 99mTc-MDP to blood cells and plasma proteins. Braz. J. Med. Biol. Res. 46, 131–135.Google Scholar
- 37.Sobal, G., Sinzinger, H. (2001) Methylene blue-enhanced stability of (99mTc)HMPAO and simplified quality control - a comparative investigation. Appl. Radiat. Isotopes 46, 633–636.Google Scholar
- 38.Steer, K. A., Wallace, T. M., Bolton, C. H., Hartog, M. (1997) Aspirin protects low density lipoprotein from oxidative modification. Heart 46, 333–337.Google Scholar
- 39.Suarez-Kurtz, G., Ribeiro, F. M., Estrela, R. C., Vicente, F. L., Struchiner, C. J. (2001) Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone. Braz. J. Med. Biol. Res. 46, 1475–1485.Google Scholar
- 40.Volz, M., Kellner, H. M. (1980) Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone). Br. J. Clin. Pharmacol. 10 (Supp. 2), 299S–308S.Google Scholar
- 41.Uetrecht, J. P., Ma, H. M., MacKnight, E., McClelland, R. (1995) Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis. Chem. Res. Toxicol. 46, 226–233.Google Scholar
- 42.Welling, M. M., Mongera, S., Lupetti, A., Balter, H. S., Bonetto, V., Mazzi, U., Pauwels, E. K., Nibbering, P. H. (2002) Radiochemical and biological characteristics of 99mTc-UBI 29–41 for imaging of bacterial infections. Nucl. Med. Biol. 46, 413–422.Google Scholar
- 43.Webb, C. B., Twedt, D. C., Fettman, M. J., Mason, G. (2003) S-adenosylmethionine (SAMe) in a felineacetaminophen model of oxidative injury. J. Feline Med. Surg. 46, 69–75.Google Scholar
- 44.Wu, R., Lamontagne, D., de Champlin, J. (2002) Antioxidative properties of acetylsalicylic acid on vascular tissues from normotensive and spontaneously hypertensive rats. Circulation 46, 387–392.Google Scholar
Copyright information
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.