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Acta Biologica Hungarica

, Volume 52, Issue 2–3, pp 315–323 | Cite as

Multifunctional Cytokinesis Genes in Schizosaccharomyces pombe

  • M. SipiczkiEmail author
  • Ágnes Grallert
  • Erika Zilahi
  • Ida Miklös
  • Z. Szilágyi
Article

Abstract

The proper division of cells is essential for the production of viable daughter cells. In plants and fungi, the dividing cell produces a cross-wall or septum that bisects the cytoplasm. For separation of the daughter cells, the septum has to be cleaved. To study the regulation of this process, we isolated mutants defective in septum cleavage. The mutants showed highly pleiotropic phenotypes and defined 17 novel genes. The deduced amino acid sequences of the products of the cloned genes exhibited homologies to various transcription regulators of other organisms. The homologies and the pleiotropic effects of the mutations on sexual development, stress response, mitotic stability, septum initiation and septum placement indicated that these genes affect cell separation indirectly, through multifunctional regulatory modules.

Keywords

cytokinesis yeast Schizosaccharomyces transcription sterility 

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© Akadémiai Kiadó, Budapest 2001

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • M. Sipiczki
    • 1
    • 2
    Email author
  • Ágnes Grallert
    • 1
  • Erika Zilahi
    • 1
  • Ida Miklös
    • 1
  • Z. Szilágyi
    • 1
  1. 1.Department of GeneticsUniversity of DebrecenDebrecenHungary
  2. 2.Research Group of Microbial Developmental GeneticsHungarian Academy of SciencesDebrecenHungary

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