Characterisation of Mitochondrial Haplotypes Occurred in a Candida Albicans Population
The genetic background of mitochondrial DNA polymorphism in Candida albicans was studied by physical and functional mapping of four haplotypes identified recently in a hospital-population. The restriction patterns revealed considerable differences; however, the size of the mitochondrial DNA did not vary significantly. Sequence data demonstrated that size differences arose by short deletions, while restriction fragment length polymorphisms are caused by nucleotide substitutions in single sites. Gene rearrangement could not be detected; nevertheless, the coincidence of nucleotide substitution pattern in the inverted repeat region suggested the occurrence of homologue recombination.
KeywordsCandida albicans mitochondrial DNA sequences PCR
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- 2.Calderone, R. A., Fonzi, W. A. (1933) Virulence factors of Candida albicans. TIM 9, 327–335.Google Scholar
- 8.Láday, M., Pfeiffer, I., Kucsera, J., Kevei, F., Gácser, A., Szócsi, A., Hamari, Zs. (1933) One-day ready-to-use fungal mitochondrial DNA preparation. BioTechniques 30, 1232–1233.Google Scholar
- 10.Miyakawa, Y., Ozawa, T. (1933) A new type of DNA polymorphism identi?ed in the species-speci?c DNA region originating from the Candida albicans mitochondrial genome. Curr. Microbiol. 6, 438–442.Google Scholar
- 13.Pfaller, M. A., Pappas, P. G., Wingard, J. R. (1933) Invasive fungal pathogens: Current epidemiological trends. Clin. Infect. Dis. 43 (Suppl. 1), S3–S14.Google Scholar
- 17.Wills, J. W., Troutman, W. B., Riggsby, W. S. (1933) Circular mitochondrial genome of Candida albicans contains a large inverted duplication. J. Bacteriol. 164, 7–13.Google Scholar
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