Acta Biologica Hungarica

, Volume 66, Issue 4, pp 385–394 | Cite as

Study of in Vitro Antimicrobial and Antiproliferative Activities of Selected Saharan Plants

  • Ionut F. Palici
  • Erika Liktor-Busa
  • István Zupkó
  • Blaise Touzard
  • Mohamed Chaieb
  • Edit Urbán
  • Judit HohmannEmail author
Open Access


The aim of the present study was the evaluation of the antimicrobial and antiproliferative activities of selected Saharan species, which are applied in the traditional medicine but not studied thoroughly from chemical and pharmacological point of view. The studied plants, namely Anthyllis henoniana, Centropodia forskalii, Cornulaca monacantha, Ephedra alata var. alenda, Euphorbia gnyoniana, Helianthemum confertum, Henophyton deserti, Moltkiopsis ciliata and Spartidium saharae were collected from remote areas of North Africa, especially from the Tunisian region of Sahara. After drying and applying the appropriate extraction methods, the plant extracts were tested in antimicrobial screening assay, performed on 19 Gram-positive and -negative strains of microbes. The inhibition zones produced by plant extracts were determined by disc-diffusion method. Remarkable antibacterial activities were exhibited by extracts of Ephedra alata var. alenda and Helianthemum confertum against B. subtilis, M. catarrhalis and methicillin-resistant and non-resistant S. aureus. Minimum inhibitory concentrations of these two species were also determined. Antiproliferative effects of the extracts were evaluated against 4 human adherent cell lines (HeLa, A431, A2780 and MCF7). Notable cell growth inhibition was found for extract of Helianthemum confertum and Euphorbia guy’oniana. Our results provided data for selection of some plant species for further detailed pharmacological and phytochemical examinations.


Saharan plants Ephedra alata var. alenda Helianthemum confertum antibacterial activity antiproliferative activity 


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© Akadémiai Kiadó, Budapest 2015

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Authors and Affiliations

  • Ionut F. Palici
    • 1
  • Erika Liktor-Busa
    • 2
  • István Zupkó
    • 3
  • Blaise Touzard
    • 4
  • Mohamed Chaieb
    • 5
  • Edit Urbán
    • 6
  • Judit Hohmann
    • 2
    Email author
  1. 1.Department of Pharmaceutical BotanyUniversity of Medicine and PharmacyTimisoaraRomania
  2. 2.Department of PharmacognosyUniversity of SzegedSzegedHungary
  3. 3.Department of Pharmacodynamics and BiopharmacyUniversity of SzegedSzegedHungary
  4. 4.Department of Community Ecology, UMR INRA BIOGECOUniversity of BordeauxPessacFrance
  5. 5.Department of Biology and Ecology of Arid Land, UR 11ES71University of SfaxSfaxTunisia
  6. 6.Institute of Clinical MicrobiologyUniversity of SzegedSzegedHungary

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