Benzene Derivatives Produced by Fusarium Graminearum


Using NMR spectroscopy benzene derivatives were detected in mycelia of Fusarium graminearum, a pathogen of wheat and maize. In previous studies F. graminearum was found to cause cancer to humans and benzene derivatives were detected in breath of cancer sufferers. Surprisingly, no study found benzene derivatives to be the cancerous agents in F. graminearum. In this study we detected benzene derivatives in F. graminearum and propose to study their role as cancer agents.


  1. 1.

    ACD/Structure Elucidator, version 12.01. Advanced Chemistry Development, Inc., Toronto, O., Canada., 2014.

  2. 2.

    Bucci, T., Hansen, D. K., Laborde, J. B. (1996) Leucoencephalomacia and hemorrhage in the brain of rabbits gavaged with mycotoxin fumonisin B1. Nat. Toxins 4, 51–52.

    CAS  Article  Google Scholar 

  3. 3.

    Desjardins, A. E., Hohn, T. M. (1997) Mycotoxins in plant pathogenesis. Mol. Plant Microbe In. 10, 147–152.

    CAS  Article  Google Scholar 

  4. 4.

    Desjardins, A. E., Hohn, T. M., McCormick, S. P. (1993) Trichothecene biosynthesis in Fusarium species: chemistry, genetics, and significance. Microbiol. Mol. Biol. Rev. 57, 595–604.

    CAS  Google Scholar 

  5. 5.

    Goswami, R. S., Kistler, H. C. (2004) Heading for disaster: Fusarium graminearum on cereal crops. Mol. Plant Pathol. 5, 515–525.

    CAS  Article  Google Scholar 

  6. 6.

    Fandohan, P., Hell, K., Marasas, W. F. O., Winfgield, M. J. (2003) Infection of maize by Fusarium species and contamination with fumonisin in Africa. Afr. J. Biotechnol. 2, 570–579.

    CAS  Article  Google Scholar 

  7. 7.

    Marasas, W. F. O., Kellerman, T. S., Gelderblom, W. C. A., Coetzer, J. A. W., Thiel, P. G., Van Der Lugt, J. J. (1988) Leukoencephalomalacia in horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res. 55, 197–203.

    CAS  Google Scholar 

  8. 8.

    NMRShiftDB Servers (2014) NMRShiftDB, Ref type: online source. Available from:

    Google Scholar 

  9. 9.

    Peraica, M., Radic, B., Lucic, A., Pavlovic, M. (1999) Toxic effects of mycotoxins in humans. Bull. World Health Organ. 77, 754–766.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. 10.

    Phillip, M., Gleeson, K., Hughes, J. M. B., Greenberg, J., Cataneo, R. N., Baker, L., McVay, W. P. (1999) Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 353, 1930–1933.

    Article  Google Scholar 

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Correspondence to Khayalethu Ntushelo.

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Ntushelo, K., Setshedi, I. Benzene Derivatives Produced by Fusarium Graminearum. BIOLOGIA FUTURA 66, 246–248 (2015).

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  • Fusarium graminearum
  • benzene derivatives
  • nuclear magnetic resonance