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Acta Biologica Hungarica

, Volume 66, Issue 2, pp 242–245 | Cite as

Degradation of Glutathione in Aspergillus Nidulans

  • Zsolt Spitzmüller
  • Márton Hajdú
  • István Pócsi
  • Tamás EmriEmail author
Short Communication

Abstract

Relative transcriptions of Aspergillus nidulans dug1-3 (orthologes of Saccharomyces cerevisiae DUG—deficient in utilization of glutathione—pathway genes) and ggtA encoding γ-glutamyl transpeptidase were studied under conditions inducing glutathione degradation. GgtA was induced in all cases when glutathione levels decreased, but addition of yeast extract, which moderated glutathione degradation, enhanced its induction. Although dug2 showed constitutive transcription, dug1 and dug3 were induced by carbon and nitrogen starvation and yeast extract did not caused significant changes in their relative transcription. The in silico reconstructed DUG pathway of A. nidulans is a promising candidate for cytosolic GSH degradation induced by carbon/nitrogen stress.

Keywords

Glutathione degradation γ-glutamyl transpeptidase DUG pathway carbon stress Aspergillus nidulans 

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© Akadémiai Kiadó, Budapest 2015

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  • Zsolt Spitzmüller
    • 1
  • Márton Hajdú
    • 1
  • István Pócsi
    • 1
  • Tamás Emri
    • 1
    Email author
  1. 1.Department of Biotechnology and MicrobiologyUniversity of DebrecenDebrecenHungary

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