International Journal of Hematology

, Volume 85, Issue 2, pp 116–120 | Cite as

Cutaneous langerhans cell sarcoma: a case report and review of the literature

  • Olga L. Bohn
  • Guillermo Ruiz-Argüelles
  • Leticia Navarro
  • Jesus Saldivar
  • Sergio Sanchez-Sosa
Case report


Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells that occurs in lymph nodes, liver, skin, spleen, lung, and bone. We report a case of LCS in a 47-year-old man with a 6-month history of scalp mass and cervical lym-phadenopathy. Clinical and pathologic data were available.A histologic examination demonstrated a proliferation of cells with malignant cytologic features. Because of its poorly differentiated morphologic features, hematologic and nonhematologic entities were ruled out by immunohistochemical screening with a broad panel of antibodies. Ultrastructural studies demonstrating Birbeck granules and consistent expression of CD1a, S-100 protein, and langerin by immunohistochemistry were helpful in identifying the Langerhans cell origin. Int J Hematol. 2007;85:116-120. doi: 10.1532/IJH97.NA0604

Key words

Langerhans cell sarcoma Langerhans histiocytic disorders Malignant Langerhans histiocytosis Langerhans cells Dendritic cells 


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Copyright information

© The Japanese Society of Hematology 2007

Authors and Affiliations

  • Olga L. Bohn
    • 1
  • Guillermo Ruiz-Argüelles
    • 2
  • Leticia Navarro
    • 1
  • Jesus Saldivar
    • 1
  • Sergio Sanchez-Sosa
    • 1
  1. 1.Department of PathologyUniversity Hospital UPAEPPueblaMexico
  2. 2.Department of HematologyClinica RuizPueblaMexico

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