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Chemical Papers

, Volume 69, Issue 9, pp 1237–1243 | Cite as

A new procedure for the synthesis of 2-[(4-dodecyloxyphenyl)sulfonyl]butanoic acid

  • Yun-Long Shi
  • Ling Wang
  • Chao Qian
  • Ming Tao
  • Zu-Tai Liao
  • Xin-Zhi ChenEmail author
Original Paper
  • 22 Downloads

Abstract

A new, practical and cost-effective route for scalable synthesis of 2-[(4-dodecyloxyphenyl)sulfonyl] butanoic acid, a key intermediate of a new cyan dye-forming coupler containing a sulfone group, was developed by adopting phenol as the starting material. The synthesis was accomplished in five steps with etherification, chlorosulfonation, reduction, nucleophilic reaction by C-S coupling and hydrolyzation. An important objective of the new synthetic route was the synthesis of 2-[4-(dodecyloxyphenyl)sulfonyl]butanoate. Overall yield obtained at optimized conditions increased to 66 %. The synthetic strategy was proven to be a process enabling rapid delivery of the target product with high purity.

Keywords

cyan dye-forming coupler 2-[(4-dodecyloxyphenyl)sulfonyl]butanoic acid phenol C-S coupling 

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Supplementary material

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2015

Authors and Affiliations

  • Yun-Long Shi
    • 1
  • Ling Wang
    • 1
  • Chao Qian
    • 1
  • Ming Tao
    • 2
  • Zu-Tai Liao
    • 2
  • Xin-Zhi Chen
    • 1
    Email author
  1. 1.Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological EngineeringZhejiang UniversityHangzhouChina
  2. 2.Jiangxi Renming Pharmaceutical Chemicals Ltd.JiujiangChina

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