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Chemical Papers

, Volume 69, Issue 9, pp 1231–1236 | Cite as

A facile, highly efficient and novel method for synthesis of 5-substituted 1H-tetrazoles catalysed by copper(I) chloride

  • İbrahim Esirden
  • Erhan Başar
  • Muharrem KayaEmail author
Original Paper

Abstract

The present study on tetrazole compounds, which have a wide area of application, proposes a new, simple and highly effective method. A series of 5-substituted 1H-tetrazoles were synthesised in DMF via the [3 + 2] cycloaddition reaction, in which different aryl nitriles with sodium azide were used and copper(I) chloride served as a catalyst. Short reaction times, high yields and simple procedures rendered this method attractive and useful for the organic synthesis of 5-substituted 1H-tetrazoles. A further advantage was the use of an environmentally friendly catalyst.

Keywords

5-substituted 1H-tetrazoles copper(I) chloride sodium azide [3 + 2] cycloaddition aryl nitriles 

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Supplementary material

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Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2015

Authors and Affiliations

  1. 1.Chemistry Department, Faculty of Arts and ScienceDumlupınar UniversityKütahyaTurkey
  2. 2.Biochemistry Department, Faculty of Arts and ScienceDumlupınar UniversityKütahyaTurkey

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