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Efficient synthesis of glutaric acid from l-glutamic acid via diazoniation/hydrogenation sequence

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Abstract

The practical synthetic preparation of glutaric acid has remained a major challenge to date. In the present study, glutaric acid was synthesised by way of one-pot diazoniation/hydrogenation of the readily available l-glutamic acid under aqueous conditions on a gram-scale with good yields. This is the first example of the deamination of the aliphatic primary amine via diazoniation and could afford a practical approach to the production of glutaric acid.

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  1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China

    Wei Zhang, Meng-Yun Rao, Zhong-Jun Cheng, Xiao-Yan Zhu, Kai Gao, Jian Yang, Bo Yang & Xia-Li Liao

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  1. Wei Zhang
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Zhang, W., Rao, MY., Cheng, ZJ. et al. Efficient synthesis of glutaric acid from l-glutamic acid via diazoniation/hydrogenation sequence. Chem. Pap. 69, 716–721 (2015). https://doi.org/10.1515/chempap-2015-0067

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