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Electrochemical enzymatic biosensors based on metal micro-/nanoparticles-modified electrodes: a review

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Abstract

The functions of metal structures of micro- or nano-dimensions in the sensing mechanisms of amperometric enzyme-based biosensors are considered in the light of the principles of detection of the latter. The applications of metal mono- or bimetallic nanoparticles-modified materials as catalytic electrodes in the fabrication of first-generation and the role which metal nanoparticles play in promoting or enhancing the electron transfer rates in third-generation electrochemical biosensors are reviewed. Some examples of gold NPs functionalised with enzymes via gold-thiol chemistry as a strategy for enzyme immobilisation and spatial orientation when developing amperometric biosensors are also discussed.

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  1. Department of Physical Chemistry, Plovdiv University, 24, Tsar Assen Street, BG-4000, Plovdiv, Bulgaria

    Nina D. Dimcheva & Elena G. Horozova

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Dimcheva, N.D., Horozova, E.G. Electrochemical enzymatic biosensors based on metal micro-/nanoparticles-modified electrodes: a review. Chem. Pap. 69, 17–26 (2015). https://doi.org/10.1515/chempap-2015-0011

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