, Volume 14, Issue 4, pp 504–514 | Cite as

The Sertoli cell: Novel clinical potentiality

  • Paschalia K. IliadouEmail author
  • Christos Tsametis
  • Athina Kaprara
  • Ioannis Papadimas
  • Dimitrios G. Goulis


The Sertoli cell is important for endocrine and paracrine control of spermatogenesis. Functions attributed to Sertoli cells are: (1) supportive and trophic functions for the cells of the seminiferous epithelium, (2) transport of mature spermatids towards the lumen of seminiferous tubules, (3) secretion of androgen binding protein, (4) production of substances with endocrine or paracrine action for spermatogenesis control and (5) interaction with intertubular endocrine Leydig cells. Inhibin B and anti-Müllerian hormone (AMH) are glycoproteins belonging to the transforming growth factor β (TGF-β) superfamily; they are produced almost exclusively by the Sertoli cells and have been proposed as direct markers of their function and indirect markers of spermatogenesis. Serum inhibin B and AMH concentrations seem to constitute additional diagnostic parameters in male subfertility as they reflect Sertoli cell function. Stimulated concentrations of serum inhibin B and AMH do not add clinically relevant information in subfertile men compared to basal concentrations of these hormones. Serum inhibin B and AMH concentrations correlate with testicular histology/cytology but are not superior to FSH as predictors of the presence of sperm in testicular sperm extraction (TESE)/fine needle aspiration (FNA) biopsy in men with azoospermia.

Key words

Anti-Müllerian hormone Inhibin Sertoli cell Spermatogenesis Testicular sperm extraction 


  1. 1.
    World Health Organisation 2000 WHO manual for the standardized investigation, diagnosis and management of the infertile male. Cambridge University Press, Cambridge.Google Scholar
  2. 2.
    Bhasin S, 2007 Approach to the infertile man. J Clin Endocrinol Metab 92: 1995–2004.CrossRefGoogle Scholar
  3. 3.
    Pierik FH, Burdorf A, de Jong FH, Weber RF, 2003 Inhibin B: a novel marker of spermatogenesis. Ann Med 35: 12–20.CrossRefGoogle Scholar
  4. 4.
    Holstein AF, Schulze W, Davidoff M, 2003 Understanding spermatogenesis is a prerequisite for treatment. Reprod Biol Endocrinol 1: 107.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Petersen C, Soder O, 2006 The Sertoli cell—a hormonal target and ‘super’ nurse for germ cells that determines testicular size. Horm Res 66: 153–161.PubMedGoogle Scholar
  6. 6.
    Illingworth PJ, Groome NP, Byrd W, et al, 1996 Inhibin-B: a likely candidate for the physiologically important form of inhibin in men. J Clin Endocrinol Metab 81: 1321–1325.PubMedGoogle Scholar
  7. 7.
    Meachem SJ, Nieschlag E, Simoni M, 2001 Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur J Endocrinol 145: 561–571.CrossRefGoogle Scholar
  8. 8.
    Lee MM, Donahoe PK, 1993 Mullerian inhibiting substance: a gonadal hormone with multiple functions. Endocr Rev 14: 152–164.PubMedGoogle Scholar
  9. 9.
    Teixeira J, Maheswaran S, Donahoe PK, 2001 Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. Endocr Rev 22: 657–674.PubMedGoogle Scholar
  10. 10.
    Lee MM, Donahoe PK, Hasegawa T, et al, 1996 Mullerian inhibiting substance in humans: normal levels from infancy to adulthood. J Clin Endocrinol Metab 81: 571–576.PubMedGoogle Scholar
  11. 11.
    Fenichel P, Rey R, Poggioli S, Donzeau M, Chevallier D, Pointis G, 1999 Anti-Mullerian hormone as a seminal marker for spermatogenesis in non-obstructive azoospermia. Hum Reprod 14: 2020–2024.CrossRefGoogle Scholar
  12. 12.
    Anawalt BD, Bebb RA, Matsumoto AM, et al, 1996 Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. J Clin Endocrinol Metab 81: 3341–3345.PubMedPubMedCentralGoogle Scholar
  13. 13.
    Jensen TK, Andersson AM, Hjollund NH, et al, 1997 Inhibin B as a serum marker of spermatogenesis: correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J Clin Endocrinol Metab 82: 4059–4063.PubMedPubMedCentralGoogle Scholar
  14. 14.
    Pierik FH, Vreeburg JT, Stijnen T, De Jong FH, Weber RF, 1998 Serum inhibin B as a marker of spermatogenesis. J Clin Endocrinol Metab 83: 3110–3114.CrossRefGoogle Scholar
  15. 15.
    Al-Qahtani A, Muttukrishna S, Appasamy M, et al, 2005 Development of a sensitive enzyme immunoassay for anti-Mullerian hormone and the evaluation of potential clinical applications in males and females. Clin Endocrinol (Oxf) 63: 267–273.CrossRefGoogle Scholar
  16. 16.
    Muttukrishna S, Yussoff H, Naidu M, et al, 2007 Serum anti-Mullerian hormone and inhibin B in disorders of spermatogenesis. Fertil Steril 88: 516–518.CrossRefGoogle Scholar
  17. 17.
    Isikoglu M, Ozgur K, Oehninger S, Ozdem S, Seleker M, 2006 Serum anti-Mullerian hormone levels do not predict the efficiency of testicular sperm retrieval in men with non-obstructive azoospermia. Gynecol Endocrinol 22: 256–260.CrossRefGoogle Scholar
  18. 18.
    Appasamy M, Muttukrishna S, Pizzey AR, et al, 2007 Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility. Reprod Biomed Online 14: 159–165.CrossRefGoogle Scholar
  19. 19.
    Tuttelmann F, Dykstra N, Themmen AP, Visser JA, Nieschlag E, Simoni M, 2009 Anti-Mullerian hormone in men with normal and reduced sperm concentration and men with maldescended testes. Fertil Steril 91: 1812–1819.CrossRefGoogle Scholar
  20. 20.
    Fallat ME, Siow Y, Belker AM, Boyd JK, Yoffe S, MacLaughlin DT, 1996 The presence of mullerian inhibiting substance in human seminal plasma. Hum Reprod 11: 2165–2169.CrossRefGoogle Scholar
  21. 21.
    Fujisawa M, Yamasaki T, Okada H, Kamidono S, 2002 The significance of anti-Mullerian hormone concentration in seminal plasma for spermatogenesis. Hum Reprod 17: 968–970.CrossRefGoogle Scholar
  22. 22.
    Mostafa T, Amer MK, Abdel-Malak G, et al, 2007 Seminal plasma anti-Mullerian hormone level correlates with semen parameters but does not predict success of testicular sperm extraction (TESE). Asian J Androl 9: 265–270.CrossRefGoogle Scholar
  23. 23.
    Duvilla E, Lejeune H, Trombert-Paviot B, Gentil-Perret A, Tostain J, Levy R, 2008 Significance of inhibin B and anti-Mullerian hormone in seminal plasma: a preliminary study. Fertil Steril 89: 444–448.CrossRefGoogle Scholar
  24. 24.
    Goulis DG, Iliadou PK, Tsametis C, et al, 2008 Serum anti-Müllerian hormone levels differentiate control from subfertile men but not men with different causes of subfertility. Gynecol Endocrinol 24: 158–160.CrossRefGoogle Scholar
  25. 25.
    Andersson AM, Petersen JH, Jorgensen N, Jensen TK, Skakkebaek NE, 2004 Serum inhibin B and follicle-stimulating hormone levels as tools in the evaluation of infertile men: significance of adequate reference values from proven fertile men. J Clin Endocrinol Metab 89: 2873–2879.CrossRefGoogle Scholar
  26. 26.
    Adamopoulos D, Kapolla N, Nicopoulou S, Pappa A, Koukkou E, Gregoriou A, 2003 Assessment of Sertoli cell functional reserve and its relationship to sperm parameters. Int J Androl 26: 215–225.CrossRefGoogle Scholar
  27. 27.
    Foresta C, Bettella A, Merico M, Garolla A, Ferlin A, Rossato M, 2002 Use of recombinant human follicle-stimulating hormone in the treatment of male factor infertility. Fertil Steril 77: 238–244.CrossRefGoogle Scholar
  28. 28.
    Kinniburgh D, Anderson RA, 2001 Differential patterns of inhibin secretion in response to gonadotrophin stimulation in normal men. Int J Androl 24: 95–101.CrossRefGoogle Scholar
  29. 29.
    Young J, Chanson P, Salenave S, et al, 2005 Testicular anti-Mullerian hormone secretion is stimulated by recombinant human FSH in patients with congenital hypogonadotropic hypogonadism. J Clin Endocrinol Metab 90: 724–728.CrossRefGoogle Scholar
  30. 30.
    Tsametis C, Mintziori G, Iliadou PK, Tarlatzis BC, Papadimas I, Goulis DG, 2011 Dynamic endocrine test of inhibin B and anti-Müllerian hormone in men with non-obstructive azoospermia. Gynecol Endocrinol 27: 661–665.CrossRefGoogle Scholar
  31. 31.
    Goulis DG, Tsametis C, Iliadou PK, et al, 2009 Serum inhibin B and anti-Müllerian hormone are not superior to follicle-stimulating hormone as predictors of the presence of sperm in testicular fine-needle aspiration in men with azoospermia. Fertil Steril 91: 1279–1284.CrossRefGoogle Scholar
  32. 32.
    Toulis KA, Iliadou PK, Venetis CA, et al, 2010 Inhibin B and anti-Mullerian hormone as markers of persistent spermatogenesis in men with non-obstructive azoospermia: a meta-analysis of diagnostic accuracy studies. Hum Reprod Update 16: 713–724.CrossRefGoogle Scholar

Copyright information

© Hellenic Endocrine Society 2015

Authors and Affiliations

  • Paschalia K. Iliadou
    • 1
    Email author
  • Christos Tsametis
    • 1
  • Athina Kaprara
    • 1
  • Ioannis Papadimas
    • 1
  • Dimitrios G. Goulis
    • 1
  1. 1.Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical SchoolAristotle University of Thessaloniki, Papageorgiou General HospitalThessalonikiGreece

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